Synthesis and acetylcholinesterase enzyme inhibitory effects of some novel 4,5-Dihydro-1H-1,2,4-triazol-5-one derivatives; an in vitro and in silico study
In this study, a series of novel Schiff bases (4a-4h) containing 1, 2, 4-triazole structure were
synthesized through a condensation reaction of 3-alkyl (aryl)-4-amino-4, 5-dihydro-1 H-1, 2 …
synthesized through a condensation reaction of 3-alkyl (aryl)-4-amino-4, 5-dihydro-1 H-1, 2 …
Novel 3-phenyl-1-(alkylphenyl)-9-oxa-4-azaphenanthren-10-ones as inhibitors of some enzymes: synthesis, characterization, biological evaluation and molecular …
DB Salah, A Chakchouk-Mtibaa, L Mellouli… - Journal of …, 2022 - Taylor & Francis
A series of novel 3-phenyl-1-(alkylphenyl)-9-oxa-4-azaphenanthren-10-ones and (E)-1-
phenyl-3-(aryl) prop-2-en-1-ones were synthesized and characterized by IR, 1H NMR, 13C …
phenyl-3-(aryl) prop-2-en-1-ones were synthesized and characterized by IR, 1H NMR, 13C …
Experimental and theoretical investigations, enzyme inhibition activity and docking study of 5-methyl-4-(2-(piperazin-1-yl) ethyl)-2, 4-dihydro-3H-1, 2, 4-triazol-3-one
methyl-4-(2-(piperazin-1-yl) ethyl)-2, 4-dihydro-3H-1, 2, 4-triazol-3-one (I), title compound
was synthesized and characterized by FTIR, NMR (1 H-and 13 C NMR) and Mass …
was synthesized and characterized by FTIR, NMR (1 H-and 13 C NMR) and Mass …
Novel quinazolin–sulfonamid derivatives: Synthesis, characterization, biological evaluation, and molecular docking studies
N Sepehri, M Mohammadi-Khanaposhtani… - Journal of …, 2022 - Taylor & Francis
In the design of novel drugs, the formation of hybrid molecules via the combination of
several pharmacophores can give rise to compounds with interesting biochemical profiles. A …
several pharmacophores can give rise to compounds with interesting biochemical profiles. A …
Design, synthesis, DFT, molecular docking, and biological evalution of pyrazole derivatives as potent acetyl cholinestrease inhibitors
Alzheimer's disease (AD) is an age-related chronic and progressive neurodegenerative
disease, affecting cognition, memory, and behavior. Treatment of Alzheimer's disease's (AD) …
disease, affecting cognition, memory, and behavior. Treatment of Alzheimer's disease's (AD) …
[HTML][HTML] Synthesis characterization and evaluation of novel triazole based analogs as a acetylcholinesterase and α-glucosidase inhibitors
A series of novel triazole analogs (10a-k) bearing piperidine were synthesized in an aprotic
solvent on the most effective pharmacophore with acetylcholinesterase (AChE) and α …
solvent on the most effective pharmacophore with acetylcholinesterase (AChE) and α …
Design, synthesis, in-vitro biological profiling and molecular docking of some novel oxazolones and imidazolones exhibiting good inhibitory potential against …
I Saleem Naz Babari, M Islam, H Saeed… - Journal of …, 2024 - Taylor & Francis
Heterocyclic compounds with oxazole and imidazole rings in their structure have disclosed
momentous biological aptitudes. Taking into account their superlative attributes, the present …
momentous biological aptitudes. Taking into account their superlative attributes, the present …
Design, synthesis, extra-precision docking, and molecular dynamics simulation studies of pyrrolidin-2-one derivatives as potential acetylcholinesterase inhibitors
Inhibition of acetylcholinesterase (AChE) has been widely explored to develop novel
molecules for management of Alzheimer's disease. In past research finding reported …
molecules for management of Alzheimer's disease. In past research finding reported …
In silico exploration of promising heterocyclic molecules against both acetylcholinesterase and butyrylcholinesterase enzymes
We aimed to further explore the relationship between heterocyclic molecules and their
associated biological activities for acetylcholinesterase (AChE) and butyrylcholinesterase …
associated biological activities for acetylcholinesterase (AChE) and butyrylcholinesterase …
Synthesis, in vitro biological evaluation and in silico molecular docking studies of indole based thiadiazole derivatives as dual inhibitor of acetylcholinesterase and …
The current study was conducted to obtain hybrid analogues of indole-based thiadiazole
derivatives (1–16) in which a number of reaction steps were involved. To examine their …
derivatives (1–16) in which a number of reaction steps were involved. To examine their …
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- acetylcholinesterase inhibitors silico assessments
- acetylcholine esterase design synthesis
- acetylcholine esterase molecular docking
- acetylcholinesterase inhibitors molecular dynamics
- acetylcholine esterase biological profiling
- acetylcholinesterase inhibitors primary carbamates
- anhydrase inhibitors silico evaluation
- thiadiazole derivatives dual inhibitor