Obesity and neuroinflammation: a pathway to cognitive impairment

AA Miller, SJ Spencer - Brain, behavior, and immunity, 2014 - Elsevier
Obesity is a growing problem worldwide and is associated with a range of comorbidities,
including cognitive dysfunction. In this review we will address the evidence that obesity and …

Adipose tissue, systematic inflammation, and neurodegenerative diseases

APA Boleti, PHO Cardoso, BEF Frihling… - Neural Regeneration …, 2023 - journals.lww.com
Obesity is associated with several diseases, including mental health. Adipose tissue is
distributed around the internal organs, acting in the regulation of metabolism by storing and …

Obesity-induced neuroinflammation: beyond the hypothalamus

O Guillemot-Legris, GG Muccioli - Trends in neurosciences, 2017 - cell.com
Obesity is now a worldwide health issue. Far from being limited to weight gain, obesity is
generally associated with low-grade inflammation and with a cluster of disorders collectively …

The obese brain: mechanisms of systemic and local inflammation, and interventions to reverse the cognitive deficit

V Salas-Venegas, RP Flores-Torres… - Frontiers in Integrative …, 2022 - frontiersin.org
Overweight and obesity are now considered a worldwide pandemic and a growing public
health problem with severe economic and social consequences. Adipose tissue is an organ …

Obesity-induced inflammation: connecting the periphery to the brain

O Le Thuc, C García-Cáceres - Nature Metabolism, 2024 - nature.com
Obesity is often associated with a chronic, low-grade inflammatory state affecting the entire
body. This sustained inflammatory state disrupts the coordinated communication between …

Neuropsychiatric comorbidity in obesity: role of inflammatory processes

N Castanon, J Lasselin, L Capuron - Frontiers in endocrinology, 2014 - frontiersin.org
Neuropsychiatric symptoms are frequent in obesity. In addition to their substantial economic
and health impact, these symptoms significantly interfere with the quality of life and social …

The role of hypothalamic inflammation in diet-induced obesity and its association with cognitive and mood disorders

S Dionysopoulou, E Charmandari, A Bargiota… - Nutrients, 2021 - mdpi.com
Obesity is often associated with cognitive and mood disorders. Recent evidence suggests
that obesity may cause hypothalamic inflammation. Our aim was to investigate the …

Role of neuroinflammation in the emotional and cognitive alterations displayed by animal models of obesity

N Castanon, G Luheshi, S Layé - Frontiers in neuroscience, 2015 - frontiersin.org
Obesity is associated with a high prevalence of mood disorders and cognitive dysfunctions
in addition to being a significant risk factor for important health complications such as …

Hypothalamic inflammation and gliosis in obesity

MD Dorfman, JP Thaler - Current Opinion in Endocrinology …, 2015 - journals.lww.com
There is growing evidence that obesity is associated with brain inflammation in humans,
particularly in the hypothalamus where its presence may disrupt body weight control and …

Obesity, inflammation and cognition

EC Spyridaki, PD Avgoustinaki, AN Margioris - Current Opinion in …, 2016 - Elsevier
Highlights•Obesity causes inflammation within adipose tissue which later spreads
systematically.•Obesity-induced inflammation also spreads into the brain affecting key …