PTEN over-expression by resveratrol in acute lymphoblastic leukemia cells along with suppression of AKT/PKB and ERK1/2 in genotoxic stress

A Ghorbani, H Zand, M Jeddi-Tehrani… - Journal of natural …, 2015 - Springer
The bioactive components of dietary phytochemicals are in the spotlight of research
institutes, due to their significant antioxidant activities and health-promoting properties …

[PDF][PDF] Preliminary results indicate resveratrol affects proliferation and apoptosis of leukemia cells by regulating PTEN/PI3K/AKT pathway.

J Meng, GJ Liu, JY Song, L Chen… - European Review for …, 2019 - europeanreview.org
OBJECTIVE: PTEN-PI3K/AKT signaling pathway is widely involved in the regulation of cell
proliferation, cell cycle, apoptosis, and invasion. Resveratrol (Resv) is a natural botanical …

[HTML][HTML] Side-effects of resveratrol in HepG2 cells: reduced pten and increased bcl-xl mRNA expression

M Zheng, R Chen, H Zhong, Q Lin… - Molecular …, 2012 - spandidos-publications.com
Resveratrol is a natural compound present in red grapes and red wine, and is often
consumed in the human diet. The chemopreventive and chemotherapeutic potential of …

Resveratrol inhibits glioblastoma cells and chemoresistance progression through blockade P-glycoprotein and targeting AKT/PTEN signaling pathway

Y Zhang, Z Zhang, M Mousavi, A Moliani… - Chemico-Biological …, 2023 - Elsevier
Malignant gliomas have been categorized as a debilitating class of brain tumors that are
resistant to radiation and chemotherapeutic drugs, and have a poor prognosis. Hyper …

Resveratrol-induced growth inhibition in MDA-MB-231 breast cancer cells is associated with mitogen-activated protein kinase signaling and protein translation

M Alkhalaf - European Journal of Cancer Prevention, 2007 - journals.lww.com
Abstract Resveratrol (3, 4′, 5-trans-trihydroxystilbene) is a natural compound found in
grapes and several medicinal plants and has been shown to have anticancer effects on …

Effect of resveratrol in regulating proliferation and apoptosis of rectal cancer cells via up-regulating PTEN

LJ Lao, XJ Song, J Xu - Zhongguo Zhong yao za zhi= Zhongguo …, 2017 - europepmc.org
To analysis the relative expression of PTEN (phosphatase and tensin homology deleted on
chromosome ten) in rectal cancer cell lines and the effects of resveratrol on cell proliferation …

Nuclear factor-kappaB as a switch in regulation of resveratrol-mediated apoptosis and erythrocytic differentiation in human leukaemia cells

HF Liao, AJ Cheng, HT Huang, ML Shen, TK Hei… - Food chemistry, 2012 - Elsevier
Resveratrol exerts functions relating apoptosis and differentiation; nonetheless, the
mechanisms remain unclear. We examined the regulation of resveratrol on apoptosis and …

Selective growth inhibition of human leukemia and human lymphoblastoid cells by resveratrol via cell cycle arrest and apoptosis induction

SK Lee, W Zhang, BJS Sanderson - Journal of agricultural and …, 2008 - ACS Publications
There is great interest in the potential chemopreventive activity of resveratrol against human
cancers. However, there are conflicting results on its growth inhibitory effect on normal cells …

The PTEN/PI3K/Akt and Wnt/β-catenin signaling pathways are involved in the inhibitory effect of resveratrol on human colon cancer cell proliferation

YZ Liu, K Wu, J Huang, Y Liu… - International …, 2014 - spandidos-publications.com
Colon cancer is one of the most common malignancies and the treatments for colon cancer
have been developed substantially in the last decades, but there is still a great clinical need …

Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells

JH Kang, YH Park, SW Choi, EK Yang… - Experimental & molecular …, 2003 - nature.com
Resveratrol has been shown to possess antioxidant and anticancer activities, but little is
known on the effect of resveratrol derivatives. Recently we have isolated resveratrol and its …