RNA modifications are ubiquitous in biology, with over 100 distinct modifications. While the
vast majority were identified and characterized on abundant noncoding RNA such as tRNA …

The 3′ ends of eukaryotic mRNAs are generated by cleavage of nascent transcripts
followed by polyadenylation, which occurs at numerous sites within 3′ untranslated regions …

In eukaryotic cells, a key RNA processing step to generate mature mRNA is the coupled
reaction for cleavage and polyadenylation (CPA) at the 3′ end of individual transcripts …

Alternative RNA processing mechanisms, including alternative splicing and alternative
polyadenylation, are increasingly recognized as important regulators of gene expression …

Abstract eIF4E-binding proteins (4E-BPs) regulate translation of mRNAs in eukaryotes.
However the extent to which specific mRNA targets are regulated by 4E-BPs remains …

Regulation of gene expression by RNA processing mechanisms is now understood to be an
important level of control in mammalian cells. Regulation at the level of RNA transcription …

Expression of mature messenger RNA s (mRNAs) requires appropriate transcription
initiation and termination, as well as pre‐mRNA processing by capping, splicing, cleavage …

Increasing numbers of transcripts have been reported to transmit both protein-coding and
regulatory information. Apart from challenging our conception of the gene, this observation …

The 5′-untranslated region (5′-UTR) of mRNAs contains elements that affect expression,
yet the rules by which these regions exert their effect are poorly understood. Here, we …

Alternative cleavage and polyadenylation (APA) is a widespread mechanism to generate
mRNA isoforms with alternative 3′ untranslated regions (UTRs). The expression of …