An emerging body of evidence indicates that post-transcriptional gene regulation relies not
only on the sequence of mRNAs but also on their folding into intricate secondary structures …

The formation of mature mRNAs in vertebrates involves the cleavage and polyadenylation of
the pre-mRNA, 10–30 nt downstream of an AAUAAA or AUUAAA signal sequence. The …

Eukaryotic 3′-end formation is a critical step for mRNA maturation and involves a requisite
cleavage and polyadenylation event downstream of a polyadenylation signal. Recent …

Alternative polyadenylation (APA), which is regulated by both cis‐elements and trans‐
factors, plays an important role in post‐transcriptional regulation of eukaryotic gene …

Poly (A) tails are present on almost all eukaryotic mRNAs, and play critical roles in mRNA
stability, nuclear export, and translation efficiency. The biosynthesis and shortening of a poly …

More than half of human genes use alternative cleavage and polyadenylation (ApA) to
generate mRNA transcripts that differ in the lengths of their 3′ untranslated regions (UTRs) …

mRNA stability and translation are regulated by protein repressors that bind 3′-
untranslated regions. PUF proteins provide a paradigm for these regulatory molecules: like …

Abstract mRNA polyadenylation is an essential step for the maturation of almost all
eukaryotic mRNAs, and is tightly coupled with termination of transcription in defining the 3 …

3′ UTRs play important roles in the gene regulation network via their influence on mRNA
stability, translational efficiency, and subcellular localization. For a given gene, 3′ UTRs of …

Abstract Polyadenylation [poly (A)] signals (PAS) are a defining feature of eukaryotic protein-
coding genes. The central sequence motif AAUAAA was identified in the mid-1970s and …