Polyadenylation of mRNA leads to increased protein expression in response to diverse
stimuli, but it is difficult to identify mRNAs that become polyadenylated in living cells. Here …

In recent years views of eukaryotic gene expression have been transformed by the finding
that enormous diversity can be generated at the RNA level. Advances in technologies for …

Alternative initiation, splicing, and polyadenylation are key mechanisms used by many
organisms to generate diversity among mature mRNA transcripts originating from the same …

Vertebrate polyadenylation sites are identified by the AAUAAA signal and by GU‐rich
sequences downstream of the cleavage site. These are recognized by a heterotrimeric …

The eukaryotic Puf proteins bind 3′ untranslated region (UTR) sequence elements to
regulate the stability and translation of their target transcripts, and such regulatory events are …

Regulatory complexes formed on mRNAs control translation, stability, and localization.
These complexes possess two activities: one that binds RNA and another—the effector …

Expression of crs1 pre-mRNA, encoding a meiotic cyclin, is blocked in actively growing
fission yeast cells by a multifaceted mechanism. The most striking feature is that in …

The presence of a polyadenylation signal in the repeat (R) region of the HIV-1 genome,
which is located at both the 5′ and 3′ ends of the viral transcripts, requires differential …

Polyadenylation is the RNA processing step that completes the maturation of nearly all
eukaryotic mRNAs. It is a two-step nuclear process that involves an endonucleolytic …

The ability to selectively activate or inhibit gene expression is fundamental to understanding
complex cellular systems and developing therapeutics. Recent studies have demonstrated …