In mammals, there is a complex and intriguing relationship between DNA repair and
gametogenesis. DNA repair mechanisms are involved not only in the repair of different types …

The DNA in the cell needs to be constantly repaired to ensure fidelity of DNA replication, to
maintain genome stability and to ensure propagation of species. The DNA repair and …

The DNA mismatch repair (MMR) family functions in a variety of contexts to preserve
genome integrity in most eukaryotes. In particular, members of the MMR family are involved …

Mammalian meiosis differs from that seen in lower eukaryotes in several respects, not least
of which is the added complexity of dealing with chromosomal interactions across a much …

Defects in meiotic recombination in many organisms result in arrest because of activation of
a meiotic checkpoint (s). The proximal defect that triggers this checkpoint in mammalian …

Background Meiotic checkpoints ensure the production of gametes with the correct
complement and integrity of DNA; in metazoans, these pathways sense errors and …

Spermatogenesis is a complex process of proliferation and differentiation during male germ
cell development involving mitosis, meiosis and spermiogenesis. Endogenous and …

The fundamental underlying paradigm of sexual reproduction is the production of male and
female gametes of sufficient genetic difference and quality that, following syngamy, they …

Meiosis in human oocytes is a highly error-prone process with profound effects on germ cell
and embryo development. The synaptonemal complex protein 3 (SYCP3) transiently …

During meiosis, numerous DNA double-strand breaks (DSBs) are formed as part of the
normal developmental program. This seemingly destructive behavior is necessary for …