Discerning which mediators drive pathogenesis in chronic inflammatory diseases can be
complex: immune cells can release various pathogenic cytokines, and numerous cytokines …

Targeted cytokine inhibition has modified our concepts of the molecular pathogenesis of
chronic inflammatory diseases—instead of sharing a homogeneous molecular …

Despite the irrefutable role of inflammation in psoriasis, a complete knowledge of what
immune cells and cytokines are involved during initiation and progression of this skin …

Abstract Interleukin-7 receptor (IL-7R) is genetically associated with susceptibility to multiple
sclerosis. Here we describe that IL-7 is essential for survival and expansion of pathogenic T …

Abstract Interleukin 6 (IL-6) has a broad effect on cells of the immune system and those not
of the immune system and often displays hormone-like characteristics that affect homeostatic …

Abstract The cytokine interleukin-12 (IL-12) was thought to have a central role in T cell–
mediated responses in inflammation for more than a decade after it was first identified …

Chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease,
spondyloarthritis and psoriasis cause significant morbidity and are a considerable burden …

Interleukin (IL)-11 is upregulated in a wide variety of fibro-inflammatory diseases such as
systemic sclerosis, rheumatoid arthritis, pulmonary fibrosis, inflammatory bowel disease …

Chronic inflammatory diseases like psoriasis, Crohn's disease (CD), multiple sclerosis (MS),
rheumatoid arthritis (RA), and others are increasingly recognized as disease entities, where …

Recent advances in genome-wide association studies (GWAS) across autoimmune and
immune-mediated diseases have augmented our understanding of pathogenic mechanisms …