Human mitochondrial glutaredoxin (Grx2) was described as the first iron–sulfur protein from
the thioredoxin superfamily of proteins. The [2Fe–2S] cluster was proposed to serve as …

The nature of the connection between mitochondrial Fe-S cluster synthesis and the iron-
sensitive transcription factor Aft1 in regulating the expression of the iron transport system in …

Glutaredoxins are ubiquitous oxidoreductases which are similar to thioredoxins and possess
a typical glutathione-reducible CxxC or CxxS active site. We present here the current …

The transcription factors Aft1 and Aft2 from Saccharomyces cerevisiae regulate the
expression of genes involved in iron homeostasis. These factors induce the expression of …

Monothiol glutaredoxins (mono-Grx) represent a highly evolutionarily conserved class of
proteins present in organisms ranging from prokaryotes to humans. Mono-Grxs have been …

Glutaredoxins represent a ubiquitous family of proteins that catalyze the reduction of
disulfide bonds in their substrate proteins by use of reduced glutathione. In an attempt to …

Since their discovery as a substrate for ribonucleotide reductase (RNR), the role of
thioredoxin (Trx) and glutaredoxin (Grx) has been largely extended through their regulatory …

Class I glutaredoxins are enzymatically active, glutathione-dependent oxidoreductases,
whilst class II glutaredoxins are typically enzymatically inactive, Fe-S cluster-binding …

Glutaredoxins are glutathione-dependent enzymes that function to reduce disulfide bonds in
vivo. Interestingly, a recent discovery indicates that some glutaredoxins can also exist in …

Glutaredoxins are members of a superfamily of thiol disulfide oxidoreductases involved in
maintaining the redox state of target proteins. In Saccharomyces cerevisiae, two …