Pharmaceutical solids are well known to be able to exist in different solid-state forms and
there are a wide variety of solid-state analytical techniques available to characterize …

The field of solid state characterization is central to the pharmaceutical industry, as drug
products are, in an overwhelming number of cases, produced as solid materials. Selection of …

The existence of different solid-state forms such as polymorphs, solvates, hydrates, and
amorphous form in pharmaceutical drug substances and excipients, along with their …

The main goal of a novel drug development is to obtain it with optimal physiochemical,
pharmaceutical and biological properties. Pharmaceutical companies and scientists modify …

Objectives Solid-state transformations may occur during any stage of pharmaceutical
processing and upon storage of a solid dosage form. Early detection and quantification of …

Many drugs exist in the crystalline solid state due to reasons of stability and ease of handling
during the various stages of drug development. Crystalline solids can exist in the form of …

Active pharmaceutical ingredients (APIs), frequently delivered to the patient in the solid-state
as part of an approved dosage form, can exist in such diverse solid forms as polymorphs …

Control and selection of the properties of active pharmaceutical ingredients is a crucial part
of the drug development process. One major part of this process is the selection of an …

This review is aimed to provide to an “educated but non-expert” readership and an overview
of the scientific, commercial, and ethical importance of investigating the crystalline forms …

The solid form of a drug substance is important when developing a new chemical entity. The
crystalline form used in development is significant based on possible manufacturability …