Time-of-day-dependent variation in neuronal ischemia is well documented. Whether this
results from changes in time-of-day variation in susceptibility or from other causative factors …

Mounting evidence has demonstrated that both innate and adaptive immune cells infiltrate
into the brain after ischemic stroke. T cell invasion has been found in the ischemic region up …

The profound damage to the CNS caused by ischemic lesions has been well documented.
Yet, relatively little is known about the contribution to and effects on the immune system …

T-lymphocytes have a multifaceted role in ischemic stroke, but the majority of studies have
been conducted in young mice, which may limit the translational value of these findings …

Background and Purpose The inflammatory response within cerebral infarcts may have an
influence on tissue damage. Since old animals with an impaired immune response have …

The pathophysiology of stroke is governed by immune reactions within and remote from the
injured brain. Hypertension, a major cause and comorbidity of stroke, entails systemic …

Ischemic stroke is a leading cause of death and disability in the United States. It is known
that males and females respond differently to stroke. Depending on age, the incidence …

The immune system is regulated by circadian clocks within the brain and immune cells.
Environmental circadian disruption (ECD), consisting of a 6-h phase advance of the light …

Local and peripheral immune responses are activated after ischemic stroke. In our present
study, we investigated the temporal distribution, location, induction, and function of …

All living organisms on Earth demonstrate rhythms in biological function, which are
approximately tied to the 24-hour cycle of a single day and night. The term diurnal is …