Metabolic engineering is an integrating methodology of analysis and synthesis for the
improvement of flux distribution of metabolic pathways in complicated bioprocesses, which …

Microorganisms are widely used to produce valuable compounds. Because thousands of
metabolic reactions occur simultaneously and many metabolic reactions are related to target …

It is widely acknowledged that in order to establish sustainable societies, production
processes should shift from petrochemical-based processes to bioprocesses. Because …

Rational engineering of metabolism is important for bio-production using microorganisms.
Metabolic design based on in silico simulations and experimental validation of the metabolic …

Recent metabolic engineering were reviewed for the production of useful metabolites.
Although much attention has been paid to metabolic engineering with some practical …

Metabolic engineering is not another form of classic manipulation of intermediary
metabolism; rather, it is the purposeful design of metabolic networks. The metabolic …

The improvement of production processes to achieve commercially viable production levels
is a prerequisite to any bioprocess. Currently, production strains are enhanced using a …

Highlights•Systems biology enables metabolic engineering design.•Metabolic engineering
targets can be identified by systems biology tools.•Integrating systems biology and metabolic …

Metabolic engineering has emerged in recent years as the field concerned with the
improvement of cells using modern genetic tools. It comprises a synthesis step that …

Metabolic engineering is the directed improvement of cellular properties through the
modification of specific biochemical reactions or the introduction of new ones, with the use of …