Several years ago, we described Myc as “the oncogene from hell”, since evidence had just
emerged that Myc, aside from being responsible for cell-cycle progression and tumor …

The transcription factor MYC plays a pivotal role in regulating various cellular processes and
has been implicated in tumorigenesis across multiple cancer types. MYC has emerged as a …

The MYC proto-oncogene has been implicated in the pathogenesis of most types of human
tumors. MYC activation alone in many normal cells is restrained from causing tumorigenesis …

The role of the microenvironment in cancer development is being increasingly appreciated.
This paper will review data that highlight an emerging distinction between two different …

Similarly to our healthy organs, the tumor tissue also constitutes an ecosystem. This implies
that stromal cells acquire an altered phenotype in tandem with tumor cells, thereby …

Myc is a cellular oncogene frequently deregulated in cancer that has the ability to stimulate
cellular growth by promoting a number of proliferative and pro-survival pathways. Here we …

Cancers are not just masses of malignant cells but complex 'rogue'organs, to which many
other cells are recruited and can be corrupted by the transformed cells. Interactions between …

This book's initial title was “Tumor Microenvironment.” However, due to the current great
interest in this topic, we were able to assemble more chapters than would fit in one book …

What has been will be again, what has been done will be done again; there is nothing new
under the sun (Ecclesiastes 1: 9) Stephen Paget was the conceptual father of the role played …

The Myc family of oncogenes is deregulated in many types of cancer, and their over-
expression is often correlated with poor prognosis. The Myc family members are …