Background. Metabolism in the tumor microenvironment can play a critical role in
tumorigenesis and tumor aggression. Metabolic coupling may occur between tumor …

The role of several metabolic changes, such as hypoxia and acidosis, in the tumour
environment has caught the attention of researchers in cancer progression and invasion …

Introduction Monocarboxylate transporters (MCTs) 1–4 are lactate transporters crucial for
cancers cells adaption to upregulated glycolysis. Herein, we aimed to explore their …

Energy production by cancer is driven by accelerated glycolysis, independently of oxygen
levels, which results in increased lactate production. Lactate is shuttled to and from cancer …

Monocarboxylate transporters (MCTs) are transmembrane proteins that control the lactate
metabolism and associated with poor prognosis in solid tumours including breast cancer …

Abstract Background Soft tissue sarcomas (STSs) are a group of neoplasms, which, despite
current therapeutic advances, still confer a poor outcome to half of the patients. As other …

Background: Monocarboxylate transporter isoform 1 (MCT1) is an important molecule in
mediating lactate transportation. Recent studies have shown an oncogenic role of MCT1 in …

Background Endometrial cancer (EC) is a major health concern due to its rising incidence.
Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis …

Abstract Purpose Monocarboxylate transporter 4 (MCT4) is a critical component in the
glycolytic metabolism of cancer cells, and is also important for malignant behavior. We …

The tumour microenvironment is known to be acidic due to high glycolytic rates of tumour
cells. Monocarboxylate transporters (MCTs) play a role in extracellular acidification, which is …