Progressive multiple sclerosis

D Ontaneda, RJ Fox - Current opinion in neurology, 2015 - journals.lww.com
PMS represents a significant challenge, as the pathogenesis of the disease is not well
understood, no validated outcome metrics have been established and clinical trial …

Primary progressive multiple sclerosis: current therapeutic strategies and future perspectives

A Gajofatto, M Turatti, MD Benedetti - Expert review of …, 2017 - Taylor & Francis
Introduction: Multiple sclerosis (MS) is a chronic inflammatory condition of the central
nervous system with heterogeneous features. Primary progressive (PP) MS is a rare disease …

Challenge of progressive multiple sclerosis therapy

AJ Thompson - Current opinion in neurology, 2017 - journals.lww.com
Challenge of progressive multiple sclerosis therapy : Current Opinion in Neurology Challenge
of progressive multiple sclerosis therapy : Current Opinion in Neurology Log in or Register …

Towards treating progressive multiple sclerosis

A Thompson, O Ciccarelli - Nature Reviews Neurology, 2020 - nature.com
Following extensive progress in the treatment of relapsing multiple sclerosis, the major
challenge in the field is now to develop effective therapies for progressive forms of multiple …

Primary progressive multiple sclerosis: current and future treatment options

SM Leary, AJ Thompson - CNS drugs, 2005 - Springer
Approximately 10% of patients with multiple sclerosis (MS) run a primary progressive course
characterised by an accumulation of neurological deficits without relapse or remission …

Therapeutic advances and challenges in the treatment of progressive multiple sclerosis

LE Baldassari, RJ Fox - Drugs, 2018 - Springer
Despite the fact that majority of patients with multiple sclerosis (MS) have relapsing-remitting
disease, many transition to secondary progressive disease (SPMS) over time. This transition …

Progressive MS: from pathophysiology to drug discovery

M Salvetti, D Landsman… - Multiple Sclerosis …, 2015 - journals.sagepub.com
Progressive multiple sclerosis (MS) will be a major area of research interest for years to
come. No treatments exist and success in the field will generalise to other neurological …

[HTML][HTML] The future of progressive multiple sclerosis therapies

CW Hollen, MMP Soldán, JR Rinker, RI Spain - Federal …, 2020 - ncbi.nlm.nih.gov
Conclusions Developing effective disease modifying therapies that slow or stop the gradual
accumulation of neurologic disability in progressive MS represents a critical unmet need. As …

Setting a research agenda for progressive multiple sclerosis: the International Collaborative on Progressive MS

RJ Fox, A Thompson, D Baker… - Multiple Sclerosis …, 2012 - journals.sagepub.com
Despite significant progress in the development of therapies for relapsing MS, progressive
MS remains comparatively disappointing. Our objective, in this paper, is to review the current …

Progressive multiple sclerosis: characteristics and management

K Hawker - Neurologic clinics, 2011 - neurologic.theclinics.com
Multiple sclerosis (MS) is thought to be an autoimmune disease of the central nervous
system preferentially affecting women and young people aged 20 to 40 years and is one of …