Integrating proteomics and metabolomics characterizes active pathways and potential drug targets in small cell lung cancer
PA Stewart, J Li, KJ Fisher, S Dhungana, D Stewart… - Cancer Research, 2015 - AACR
Small cell lung cancer (SCLC) accounts for 13-15% of all new lung cancer cases and
represents the sixth most commonly diagnosed cancer in the US. However, it is an …
represents the sixth most commonly diagnosed cancer in the US. However, it is an …
A22 Integrated Proteometabolomic Analysis Reveals Metabolic Vulnerabilities in Small-Cell Lung Cancer
A Prabhu, K Scott, P Stewart, D Grass… - Journal of Thoracic …, 2020 - jto.org
Small-cell lung cancer (SCLC) is the third most common histology of lung cancers and is
extremely aggressive and highly metastatic. Although SCLC responds well to radiation and …
extremely aggressive and highly metastatic. Although SCLC responds well to radiation and …
Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies
Q Liu, J Zhang, C Guo, M Wang, C Wang, Y Yan, L Sun… - Cell, 2024 - cell.com
We performed comprehensive proteogenomic characterization of small cell lung cancer
(SCLC) using paired tumors and adjacent lung tissues from 112 treatment-naive patients …
(SCLC) using paired tumors and adjacent lung tissues from 112 treatment-naive patients …
[HTML][HTML] Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review
AM Elshoeibi, B Elsayed, MZ Kaleem, MR Elhadary… - Cancers, 2023 - mdpi.com
Simple Summary Our study centers on refining the diagnosis of small-cell lung cancer
(SCLC), a unique subtype with distinct therapeutic implications compared to other lung …
(SCLC), a unique subtype with distinct therapeutic implications compared to other lung …
Proteomics: A new dimension to decode small cell lung cancer
H Chen, BJ Drapkin, JD Minna - Cell, 2024 - cell.com
Small cell lung cancer (SCLC) is a recalcitrant malignancy. Conquering it will require deep
insight into its biology. In this issue of Cell, Liu and colleagues describe proteomic and …
insight into its biology. In this issue of Cell, Liu and colleagues describe proteomic and …
Integrated omics and gene expression analysis identifies the loss of metabolite–Metabolite correlations in small cell lung cancer
Background and objective Small cell lung cancer (SCLC) is the most aggressive type of lung
carcinoma with high metastatic potential and chemoresistance upon relapse. Cancer cells …
carcinoma with high metastatic potential and chemoresistance upon relapse. Cancer cells …
Target identification in small cell lung cancer via integrated phenotypic screening and activity-based protein profiling
To overcome hurdles in identifying key kinases in small cell lung cancer (SCLC), we
integrated a target-agnostic phenotypic screen of kinase inhibitors with target identification …
integrated a target-agnostic phenotypic screen of kinase inhibitors with target identification …
[HTML][HTML] 1662P Comprehensive analysis of the metabolic enzymes in patients with small cell lung cancer using a large-scale targeted proteomics assay
G Toyokawa, M Kodama, N Haratake… - Annals of …, 2021 - annalsofoncology.org
Background Small cell lung cancer (SCLC) is a devastating subtype of lung cancer, and its
biological, clinical and genetic characteristics differ from those associated with non-small …
biological, clinical and genetic characteristics differ from those associated with non-small …
32P Untargeted metabolomics and lipidomics identified four subtypes of small cell lung cancer
C Zhang, X Shang, H Wang - Annals of Oncology, 2022 - annalsofoncology.org
Background Small cell lung cancer (SCLC) is a heterogeneous malignancy with dismal
prognosis. As molecular subtyping of SCLC with distinct genomic and transcriptional profiles …
prognosis. As molecular subtyping of SCLC with distinct genomic and transcriptional profiles …
Untargeted metabolomics and lipidomics identified four subtypes of small cell lung cancer
C Zhang, X Shang, H Wang - Metabolomics, 2022 - Springer
Introduction Small cell lung cancer (SCLC) is a heterogeneous malignancy with dismal
prognosis. However, few studies have conducted on the metabolic heterogeneity in SCLC …
prognosis. However, few studies have conducted on the metabolic heterogeneity in SCLC …