Integrating proteomics and metabolomics characterizes active pathways and potential drug targets in small cell lung cancer

PA Stewart, J Li, KJ Fisher, S Dhungana, D Stewart… - Cancer Research, 2015 - AACR
Small cell lung cancer (SCLC) accounts for 13-15% of all new lung cancer cases and
represents the sixth most commonly diagnosed cancer in the US. However, it is an …

A22 Integrated Proteometabolomic Analysis Reveals Metabolic Vulnerabilities in Small-Cell Lung Cancer

A Prabhu, K Scott, P Stewart, D Grass… - Journal of Thoracic …, 2020 - jto.org
Small-cell lung cancer (SCLC) is the third most common histology of lung cancers and is
extremely aggressive and highly metastatic. Although SCLC responds well to radiation and …

Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies

Q Liu, J Zhang, C Guo, M Wang, C Wang, Y Yan, L Sun… - Cell, 2024 - cell.com
We performed comprehensive proteogenomic characterization of small cell lung cancer
(SCLC) using paired tumors and adjacent lung tissues from 112 treatment-naive patients …

[HTML][HTML] Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review

AM Elshoeibi, B Elsayed, MZ Kaleem, MR Elhadary… - Cancers, 2023 - mdpi.com
Simple Summary Our study centers on refining the diagnosis of small-cell lung cancer
(SCLC), a unique subtype with distinct therapeutic implications compared to other lung …

Proteomics: A new dimension to decode small cell lung cancer

H Chen, BJ Drapkin, JD Minna - Cell, 2024 - cell.com
Small cell lung cancer (SCLC) is a recalcitrant malignancy. Conquering it will require deep
insight into its biology. In this issue of Cell, Liu and colleagues describe proteomic and …

Integrated omics and gene expression analysis identifies the loss of metabolite–Metabolite correlations in small cell lung cancer

L Yu, K Li, Z Xu, G Cui, X Zhang - OncoTargets and therapy, 2018 - Taylor & Francis
Background and objective Small cell lung cancer (SCLC) is the most aggressive type of lung
carcinoma with high metastatic potential and chemoresistance upon relapse. Cancer cells …

Target identification in small cell lung cancer via integrated phenotypic screening and activity-based protein profiling

J Li, B Fang, F Kinose, Y Bai, JY Kim, YA Chen… - Molecular cancer …, 2016 - AACR
To overcome hurdles in identifying key kinases in small cell lung cancer (SCLC), we
integrated a target-agnostic phenotypic screen of kinase inhibitors with target identification …

[HTML][HTML] 1662P Comprehensive analysis of the metabolic enzymes in patients with small cell lung cancer using a large-scale targeted proteomics assay

G Toyokawa, M Kodama, N Haratake… - Annals of …, 2021 - annalsofoncology.org
Background Small cell lung cancer (SCLC) is a devastating subtype of lung cancer, and its
biological, clinical and genetic characteristics differ from those associated with non-small …

32P Untargeted metabolomics and lipidomics identified four subtypes of small cell lung cancer

C Zhang, X Shang, H Wang - Annals of Oncology, 2022 - annalsofoncology.org
Background Small cell lung cancer (SCLC) is a heterogeneous malignancy with dismal
prognosis. As molecular subtyping of SCLC with distinct genomic and transcriptional profiles …

Untargeted metabolomics and lipidomics identified four subtypes of small cell lung cancer

C Zhang, X Shang, H Wang - Metabolomics, 2022 - Springer
Introduction Small cell lung cancer (SCLC) is a heterogeneous malignancy with dismal
prognosis. However, few studies have conducted on the metabolic heterogeneity in SCLC …