Aims/hypothesis Evidence for the importance of peroxynitrite, a product of superoxide anion
radical reaction with nitric oxide, in peripheral diabetic neuropathy is emerging. The role of …

Evidence for the important role of the potent oxidant peroxynitrite in peripheral diabetic
neuropathy and neuropathic pain is emerging. This study evaluated the contribution of …

Background Peroxynitrite, a product of the reaction of superoxide with nitric oxide, causes
oxidative stress with concomitant inactivation of enzymes, poly (ADP‐ribosylation) …

Nitrosative stress, that is, enhanced peroxynitrite formation, has been documented in both
experimental and clinical diabetic neuropathy (DN), but its pathogenetic role remains …

The changes of nitric oxide synthase (NOS) activity and expression in experimental diabetic
neuropathy have not been examined. Increases in ganglia NOS might be similar to those …

Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia, and
impaired nitrergic innervation in animal models of Type 1 diabetes. The role for reactive …

Strong evidence implicates oxidative stress as a mediator of diabetes-induced
microvascular complications, including distal symmetric polyneuropathy. Dorsal root ganglia …

Whereas an important role of free radicals and oxidants in peripheral diabetic neuropathy is
well established, the contribution of nitrosative stress and, in particular, of the highly reactive …

Evidence for important roles of the highly reactive oxidant peroxynitrite in diabetic
complications is emerging. We evaluated the role of peroxynitrite in early peripheral …

TO evaluate the role of nitric oxide synthase (nNOS) in the pathogenesis of diabetic
neuropathy, we investigated nociception and nNOS expression in dorsal root ganglion …