Reduced intensity conditioning and prophylactic DLI can cure patients with high-risk acute leukaemias if complete donor chimerism can be achieved

G Massenkeil, M Nagy, M Lawang, O Rosen… - Bone marrow …, 2003 - nature.com
23 patients with ALL (n= 9) and AML (n= 14) underwent nonmyeloablative stem cell
transplantation (NST) from an HLA-identical donor after conditioning with fludarabine (180 …

Mixed chimaerism is common at the time of acute graft‐versus‐host disease and disease response in patients receiving non‐myeloablative conditioning and …

J Mattsson, M Uzunel, M Brune… - British journal of …, 2001 - Wiley Online Library
We report the clinical outcome and results of chimaerism analysis in various cell lineages of
30 patients given non‐myeloablative conditioning, followed by allogeneic stem cell …

[HTML][HTML] A modified haploidentical nonmyeloablative transplantation without T cell depletion for high-risk acute leukemia: successful engraftment and mild GVHD

M Guo, Z Sun, QY Sun, Q Han, CL Yu, DH Wang… - Biology of Blood and …, 2009 - Elsevier
Severe graft-versus-host disease (GVHD) and graft rejection still remain major complications
of haploidentical nonmyeloablative (NMA) stem cell transplantation. Recent studies have …

[HTML][HTML] Impact of prophylactic donor leukocyte infusions on mixed chimerism, graft-versus-host disease, and antitumor response in patients with advanced …

BR Dey, S McAfee, C Colby, R Sackstein… - Biology of Blood and …, 2003 - Elsevier
In an attempt to capture graft-versus-tumor effects without graft-versus-host disease (GVHD),
the authors initiated a trial of nonmyeloablative allogeneic bone marrow transplantation …

Anti‐tumour response despite loss of donor chimaerism in patients treated with non‐myeloablative conditioning and allogeneic stem cell transplantation

BR Dey, S McAfee, C Colby, K Cieply… - British journal of …, 2005 - Wiley Online Library
Based on a murine model, we conducted a series of trials of m‐myeloablative human
leucocyte antigen (HLA)‐matched or mismatched related donor stem cell transplantation …

Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow …

TR Spitzer, S McAfee, R Sackstein, C Colby… - Biology of Blood and …, 2000 - Elsevier
Mixed lymphohematopoietic chimerism can be induced in mice with bone marrow
transplantation (BMT) after a nonmyeloablative preparative regimen that includes …

Chimerism status is a useful predictor of relapse after allogeneic stem cell transplantation for acute leukemia

M Barrios, A Jiménez-Velasco, J Román-Gómez… - …, 2003 - haematologica.org
BACKGROUND AND OBJECTIVES: The role of hematopoietic chimerism after allogeneic
stem cell transplantation (SCT) for acute leukemia remains controversial. We studied the …

Chimerism analysis within 6 months of allogeneic stem cell transplantation predicts relapse in acute myeloid leukemia

C Huisman, RA De Weger, L De Vries… - Bone marrow …, 2007 - nature.com
The role of chimerism analysis as a prognostic indicator of relapse after hematopoietic stem
cell transplantation (SCT) is controversial. We monitored chimerism status by short tandem …

Chimerism and clinical outcomes of 110 recipients of unrelated donor bone marrow transplants who underwent conditioning with low-dose, single-exposure total body …

M Girgis, C Hallemeier, W Blum, R Brown, H Lin… - Blood, 2005 - ashpublications.org
We hypothesized that low-dose (550-cGy), single-exposure, high dose rate (30 cGy/min)
total body irradiation (TBI) with cyclophosphamide as conditioning for HLA-compatible …

Haploidentical stem cell transplantation in leukemia

F Aversa, A Velardi, A Tabilio, Y Reisner, MF Martelli - Blood reviews, 2001 - Elsevier
In acute leukemia patients, infusing a megadose of extensively T-cell-depleted
hematopoietic stem cells after an immuno-myeloablative conditioning regimen ensures …