Riboflavin-mediated delivery of a macromolecule into cultured human cells

SR Holladay, Z Yang, MD Kennedy, CP Leamon… - … et Biophysica Acta (BBA …, 1999 - Elsevier
Cell surface receptors for the vitamins folic acid and biotin have been previously reported to
mediate the endocytosis of vitamin-conjugated macromolecules into cultured cells. To …

Involvement of endocytic organelles in the subcellular trafficking and localization of riboflavin

SN Huang, MA Phelps, PW Swaan - Journal of Pharmacology and …, 2003 - ASPET
Previous studies by our laboratory have suggested the potential role of receptor-mediated
endocytosis components in the cellular translocation of riboflavin (vitamin B2). To delineate …

Current perspectives on the cellular uptake and trafficking of riboflavin

AB Foraker, CM Khantwal, PW Swaan - Advanced drug delivery reviews, 2003 - Elsevier
The role of riboflavin in cell maintenance and growth, and the mechanism by which it is
absorbed into various human tissues and cell lines has been extensively studied over the …

Involvement of a receptor-mediated component in cellular translocation of riboflavin

SN Huang, PW Swaan - Journal of Pharmacology and Experimental …, 2000 - ASPET
This study addresses the transport mechanism of riboflavin (vitamin B2) across intestinal
epithelium in the presence and absence of pharmacologically active compounds. A …

Selective transport of riboflavin through a liquid organic membrane

E Lambert, EC Breinlinger… - The Journal of Organic …, 1995 - ACS Publications
Riboflavin (vitamin B2), a water soluble vitamin, is an essential factor in several metabolic
pathways such as amino acid and lipid metabolism. 1 Additionally, it serves as a precursor …

Proliferation of peripheral blood mononuclear cells increases riboflavin influx (44554)

J Zempleni, DM Mock - Proceedings of the Society for …, 2000 - journals.sagepub.com
Previously we demonstrated that proliferation of peripheral blood mononuclear cells (PBMC)
causes a five-fold increase in cellular uptake of biotin; this increase is mediated by an …

A novel rhodamine− riboflavin conjugate probe exhibits distinct fluorescence resonance energy transfer that enables riboflavin trafficking and subcellular localization …

MA Phelps, AB Foraker, W Gao, JT Dalton… - Molecular …, 2004 - ACS Publications
Riboflavin (vitamin B2, RF) is taken up in eukaryotic cells via specialized transport
mechanisms. Although RF has fluorescence properties, direct microscopic visualization of …

Riboflavin uptake by rat small intestinal brush border membrane vesicles: a dual mechanism involving specific membrane binding

D Casirola, G Gastaldi, G Ferrari, S Kasai… - The Journal of membrane …, 1993 - Springer
The first step of riboflavin absorption was studied by determining the uptake of the vitamin by
rat small intestinal brush border membrane vesicles. Vesicles were incubated at 25° C in the …

Vitamin-mediated targeting as a potential mechanism to increase drug uptake by tumours

G Russell-Jones, K McTavish, J McEwan, J Rice… - Journal of inorganic …, 2004 - Elsevier
Targeted chemotherapy for cancer treatment offers a great potential advantage in tumour
treatment due to greater specificity of delivery which leads to increased dose of the cytotoxin …

A water soluble vitamin B 12-Re (i) fluorescent conjugate for cell uptake screens: use in the confirmation of cubilin in the lung cancer line A549

AR Vortherms, AR Kahkoska, AE Rabideau… - Chemical …, 2011 - pubs.rsc.org
A water soluble vitamin B12-rhenium conjugate was synthesized and used in concert with
intrinsic factor to screen for cubilin receptor-mediated uptake in lung cancer cells …