SPARSim single cell: a count data simulator for scRNA-seq data

G Baruzzo, I Patuzzi, B Di Camillo - Bioinformatics, 2020 - academic.oup.com
Motivation Single cell RNA-seq (scRNA-seq) count data show many differences compared
with bulk RNA-seq count data, making the application of many RNA-seq pre …

[HTML][HTML] The evolution of single-cell RNA sequencing technology and application: progress and perspectives

S Wang, ST Sun, XY Zhang, HR Ding, Y Yuan… - International Journal of …, 2023 - mdpi.com
As an emerging sequencing technology, single-cell RNA sequencing (scRNA-Seq) has
become a powerful tool for describing cell subpopulation classification and cell …

Recent advances in high-throughput single-cell transcriptomics and spatial transcriptomics

X Shen, Y Zhao, Z Wang, Q Shi - Lab on a Chip, 2022 - pubs.rsc.org
Single-cell RNA sequencing (scRNA-seq) has been developed for characterizing the
transcriptome of cells that are rare but of biological significance. With cell barcoding and …

[HTML][HTML] Biological and medical importance of cellular heterogeneity deciphered by single-cell RNA sequencing

RK Gupta, J Kuznicki - Cells, 2020 - mdpi.com
The present review discusses recent progress in single-cell RNA sequencing (scRNA-seq),
which can describe cellular heterogeneity in various organs, bodily fluids, and pathologies …

RSeQC: quality control of RNA-seq experiments

L Wang, S Wang, W Li - Bioinformatics, 2012 - academic.oup.com
Motivation: RNA-seq has been extensively used for transcriptome study. Quality control (QC)
is critical to ensure that RNA-seq data are of high quality and suitable for subsequent …

Single cell RNA‐sequencing: A powerful yet still challenging technology to study cellular heterogeneity

M Ke, B Elshenawy, H Sheldon, A Arora, FM Buffa - Bioessays, 2022 - Wiley Online Library
Almost all biomedical research to date has relied upon mean measurements from cell
populations, however it is well established that what it is observed at this macroscopic level …

[HTML][HTML] Single‐cell RNA sequencing in cancer research

Y Zhang, D Wang, M Peng, L Tang, J Ouyang… - Journal of Experimental …, 2021 - Springer
Single-cell RNA sequencing (scRNA-seq), a technology that analyzes transcriptomes of
complex tissues at single-cell levels, can identify differential gene expression and epigenetic …