Membrane lipid peroxidation and oxidative modification of various membrane and
associated proteins (eg, receptors, ion transporters and channels, and signal transduction …

Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative
disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases. Another important …

This review highlights the role of oxidative stress and imbalances in metal ion homeostasis
in the neurodegenerative diseases Alzheimer's disease and Parkinson's disease and in the …

This chapter reviews transition metal ion dysregulation and oxidative stress in the
pathogenesis of Alzheimer's disease. It focuses on the roles of metal ions in …

J. Neurochem.(2010) 112, 227–237. Abstract Recognizing the similarities between
Huntington's disease (HD) pathophysiology and the neurotoxicology of various metals, we …

Substantial evidence has accumulated implicating metals and free radicals in the
pathogenesis of the major neurodegenerative disorders (Parkinson's disease, Alzheimer's …

The hypothesis is presented that changes in metal ion homeostatic control, particularly of
redox-active metals such as iron and copper, in specific brain regions, leads to the …

The complex nature and genesis of oxidative damage in Alzheimer disease can be partly
answered by mitochondrial and redox-active metal abnormalities. By releasing high levels of …

Huntington's disease (HD) is caused by a dominant polyglutamine expansion within the N-
terminus of huntingtin protein and results in oxidative stress, energetic insufficiency and …

Multiple lines of evidence implicate redox-active transition metals as mediators of oxidative
stress in neurodegenerative diseases. Among the recent research discoveries is the finding …