Grape seed proanthocyanidins prevent irradiation-induced differentiation of human lung fibroblasts by ameliorating mitochondrial dysfunction

XH Yang, T Liu, B Chen, F Wang, Q Yang, XH Chen - Scientific Reports, 2017 - nature.com
Radiation-induced lung fibrosis (RILF) is a long-term adverse effect of curative radiotherapy.
The accumulation of myofibroblasts in fibroblastic foci is a pivotal feature of RILF. In the …

Grape seed pro‐anthocyanidins ameliorates radiation‐induced lung injury

Y Huang, W Liu, H Liu, Y Yang, J Cui… - Journal of cellular …, 2014 - Wiley Online Library
Radiation‐induced lung injury (RILI) is a potentially fatal and dose‐limiting complication of
thoracic radiotherapy. This study was to investigate the protective effects of grape seed pro …

The green tea extract epigallocatechin-3-gallate inhibits irradiation-induced pulmonary fibrosis in adult rats

H You, L Wei, WL Sun, L Wang… - International …, 2014 - spandidos-publications.com
The present study evaluated the effect of epigallocatechin-3-gallate (EGCG), the most
abundant catechin in green tea, on irradiation-induced pulmonary fibrosis and elucidated its …

Grape seed proanthocyanidins protect N2a cells against ischemic injury via endoplasmic reticulum stress and mitochondrial-associated pathways

K Fu, L Chen, L Miao, Y Guo… - CNS & Neurological …, 2019 - ingentaconnect.com
Background/Objective: Grape seed proanthocyanidins (GSPs) are a group of polyphenolic
bioflavonoids, which possess a variety of biological functions and pharmacological …

[HTML][HTML] Magnesium isoglycyrrhizinate ameliorates radiation-induced pulmonary fibrosis by inhibiting fibroblast differentiation via the p38MAPK/Akt/Nox4 pathway

Q Yang, P Zhang, T Liu, X Zhang, X Pan, Y Cen… - Biomedicine & …, 2019 - Elsevier
Radiation-induced pulmonary fibrosis (RIPF) is a severe complication in patients treated
with thoracic irradiation. Until now, there are no effective therapeutic drugs for RIPF. In the …

Glycyrrhetinic acid mitigates radiation-induced pulmonary fibrosis via inhibiting the secretion of TGF-β1 by Treg cells

J Chen, C Wang, X Pan, Y Zhan, W Zhou… - International Journal of …, 2024 - Elsevier
Purpose Radiation-induced pulmonary fibrosis (RIPF) is a common side effect of radiation
therapy for thoracic tumors without effective prevention and treatment methods at present …

PM014 attenuates radiation-induced pulmonary fibrosis via regulating NF-kB and TGF-b1/NOX4 pathways

SH Park, JY Kim, JM Kim, BR Yoo, SY Han, YJ Jung… - Scientific reports, 2020 - nature.com
Radiation therapy is the mainstay in the treatment of lung cancer, and lung fibrosis is a
radiotherapy-related major side effect that can seriously reduce patient's quality of life …

Rosmarinic acid prevents radiation-induced pulmonary fibrosis through attenuation of ROS/MYPT1/TGFβ1 signaling via miR-19b-3p

T Zhang, S Ma, C Liu, K Hu, M Xu… - Dose-Response, 2020 - journals.sagepub.com
The mechanism of pulmonary fibrosis caused by irradiation remains obscure. Since
rosmarinic acid (RA) have anti-oxidant and anti-inflammatory properties, we aimed to …

Verbascoside elicits its beneficial effects by enhancing mitochondrial spare respiratory capacity and the Nrf2/HO-1 mediated antioxidant system in a murine skeletal …

F Sciandra, P Bottoni, M De Leo, A Braca… - International Journal of …, 2023 - mdpi.com
Muscle weakness and muscle loss characterize many physio-pathological conditions,
including sarcopenia and many forms of muscular dystrophy, which are often also …

[HTML][HTML] Grape seed proanthocyanidins play the roles of radioprotection on normal lung and radiosensitization on lung cancer via differential regulation of the MAPK …

Y Xu, Y Huang, Y Chen, K Cao, Z Liu, Z Wan… - Journal of …, 2021 - ncbi.nlm.nih.gov
Radiation-induced lung injury (RILI) is a common serious complication and dose-limiting
factor caused by radiotherapy for lung cancer. This study was to investigate radioprotective …