Although glomerular disease remains the most common cause of end-stage renal disease
worldwide, major advances have been made recently in understanding the cellular and …

This review summarizes current understanding of the mechanisms which mediate immune
glomerular injury in glomerulonephritis. Non-inflammatory lesions resembling minimal …

This paper reviews current concepts of glomerular immune injury of both inflammatory and
noninflammatory types. In noninflammatory lesions induced by antibody alone or C5b-9, the …

The passive trapping of preformed immune complexes is responsible for some forms of
glomerulonephritis that are associated with mesangial or subendothelial deposits. The …

Although accumulation of extracellular matrix proteins and glomerular hypercellularity are
well-recognized features of progressive renal diseases, the exact pathogenetic mechanisms …

The importance of immunologic processes in the pathogenesis of glomerulonephritis has
long been recognized, and over the past 30 years considerable progress has been made …

BACKGROUND: The importance of complement in the pathophysiology of renal disease is
still being appreciated. To further address the role of this mediator system, we evaluated the …

Progressive renal disease in glomerulonephritis (GN) involves both glomerular and
interstitial processes. In the glomerulus, sclerosis occurs with progressive accumulation of …

The pathogenesis of progressive renal diseases leading to end-stage renal failure is still
largely unknown and is therefore the subject of intense investigation. Some features have …

The renal glomerulus is the specialized structure in the kidney responsible for generating
over 150 liters of plasma ultrafiltrate per day in humans. Certain characteristics of this …