Heart failure (HF) is a state of chronic deterioration of oxidative mechanisms due to
enhanced oxidative stress and consequent subcellular alterations. In this condition, oxidant …

The role of hyperuricaemia as cardiovascular risk factor has exhaustingly been debated for
decades. While the association of elevated uric acid (UA) levels with increased mortality risk …

The association between hyperuricemia and cardiovascular disease (CVD) has been
reported and studied in the past two decades. Xanthine oxidase (XO) induced uric acid (UA) …

The pathophysiologic understanding of chronic heart failure (CHF) has shifted from a mere
hemodynamic disorder to a much more complex approach including changes and …

Background—Oxidative stress may contribute to heart failure (HF) progression. Inhibiting
xanthine oxidase in hyperuricemic HF patients may improve outcomes. Methods and …

Increasing evidence suggests that serum uric acid (UA), a product of xanthine oxidase (XO),
may be a useful marker for metabolic, hemodynamic, and functional staging in heart failure …

Affecting more than 26 million people worldwide and with rising prevalence, heart failure
(HF) represents a major global health problem. Hence, further research is needed in order to …

BACKGROUND: In severe chronic heart failure (CHF) elevated serum levels of uric acid
(UA) predict poor survival. This study investigates whether hyperuricaemia (defined as …

BACKGROUND: Reactive oxygen species (ROS) have been linked to hypertrophy,
remodeling and abnormal excitation-contraction coupling. Previous data demonstrated that …

Background Oxidative stress due to purine degradation is associated with the development
of chronic heart failure (CHF). Xanthine oxidoreductase (XOR) is a rate-limiting enzyme of …