Decades of work have elucidated cytokine signalling and transcriptional pathways that
control T cell differentiation and have led the way to targeted biologic therapies that are …

Obesity generates a proinflammatory environment in adipose tissue, but the factors that
initiate this inflammatory cascade have been unclear. Three studies now show that …

Inflammation is increasingly regarded as a key process underlying metabolic diseases in
obese individuals. In particular, obese adipose tissue shows features characteristic of active …

Obesity and type-2 diabetes have increased markedly over the past few decades, in parallel.
One of the major links between these two disorders is chronic, low-grade inflammation …

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Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely
associated with a state of low-grade inflammation,. In adipose tissue chronic overnutrition …

Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which
promotes insulin resistance and type-2 diabetes. These findings raise the question of how …

Chronic inflammation characterized by T cell and macrophage infiltration of visceral adipose
tissue (VAT) is a hallmark of obesity-associated insulin resistance and glucose intolerance …

Metabolism has been shown to integrate with epigenetics and transcription to modulate cell
fate and function,,. Beyond meeting the bioenergetic and biosynthetic demands of T-cell …

Peroxisome proliferator-activated receptor-γ (PPAR-γ) is highly expressed in lipid-
accumulating macrophages of the coronary artery. In light of this, the wide-spread clinical …