Genotype Variability and Haplotype Frequency of MDR1 (ABCB1) Gene Polymorphism in Morocco
Y Kassogue, H Dehbi, S Nassereddine… - DNA and cell …, 2013 - liebertpub.com
The multidrug resistance gene (MDR1) plays an important role in the transport of a wide
range of drugs and elimination of xenobiotics from the body. Identification of polymorphisms …
range of drugs and elimination of xenobiotics from the body. Identification of polymorphisms …
Haplotype-Based Analysis of MDR1/ABCB1 Gene Polymorphisms in a Turkish Population
G Gümüş-Akay, A Rüstemoğlu, A Karadağ… - DNA and Cell …, 2010 - liebertpub.com
The three functional single-nucleotide polymorphisms (SNPs) of the MDR1 gene, C1236T,
G2677T/A, and C3435T, exhibit an interpopulation difference. In this study, we analyzed the …
G2677T/A, and C3435T, exhibit an interpopulation difference. In this study, we analyzed the …
Genetic variability and haplotype profile of MDR1 in Saudi Arabian males
AM Al-Mohizea, KM Alkharfy, KM Bagulb… - Molecular biology …, 2012 - Springer
Polymorphisms in multidrug resistance (MDR1) gene play an important role in influencing
the pharmacological action and toxicity profile of a large number of therapeutic agents, and …
the pharmacological action and toxicity profile of a large number of therapeutic agents, and …
Genetic variability and haplotype profile of MDR1 (ABCB1) in Roma and Hungarian population samples with a review of the literature
The genetic variability, haplotype profile and ethnic differences of MDR1 polymorphisms in
healthy Roma and Hungarian populations were analyzed and the results were compared …
healthy Roma and Hungarian populations were analyzed and the results were compared …
Functional Implications of Genetic Polymorphisms in the Multidrug Resistance Gene MDR1 (ABCB1)
C Pauli-Magnus, DL Kroetz - Pharmaceutical research, 2004 - Springer
The multidrug resistance (MDR1) gene product P-glycoprotein is a membrane protein that
functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …
functions as an ATP-dependent efflux pump, transporting exogenous and endogenous …
[PDF][PDF] Frequency of MDR1 single nucleotide polymorphisms in a Jordanian population, including a novel variant
The multidrug resistance gene (MDR1 or ABCB1) codes for P-glycoprotein, which plays an
important role in regulating absorption, distribution, and elimination of drugs. We examined …
important role in regulating absorption, distribution, and elimination of drugs. We examined …
Haplotype-oriented genetic analysis and functional assessment of promoter variants in the MDR1 (ABCB1) gene
H Takane, D Kobayashi, T Hirota, J Kigawa… - … of Pharmacology and …, 2004 - ASPET
Recently, a number of nucleotide variants have been described in the multidrug resistance 1
(MDR1/ABCB1) gene; however, most studies have focused on the coding region. In the …
(MDR1/ABCB1) gene; however, most studies have focused on the coding region. In the …
A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function
KL Fung, MM Gottesman - Biochimica et Biophysica Acta (BBA)-Proteins …, 2009 - Elsevier
The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …
wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant …
MDR1 (ABCB1) polymorphisms: functional effects and clinical implications
AJL Brambila-Tapia - Revista de investigacion clinica, 2013 - medigraphic.com
ABSTRACT MDR1 gene encodes for P glycoprotein (P-gp), which plays an important role in
bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three …
bioavailability and cell-toxicity limitation of a wide range of drugs and xenobiotics. Three …
Human MDR1 polymorphism: G2677T/A and C3435T have no effect on MDR1 transport activities
N Morita, T Yasumori, K Nakayama - Biochemical pharmacology, 2003 - Elsevier
The two most frequently observed single nucleotide polymorphisms (SNPs) of the human
multidrug resistance 1 (MDR1) gene are 2677G/T/A (893Ala/Ser/Thr) and 3435C/T (no …
multidrug resistance 1 (MDR1) gene are 2677G/T/A (893Ala/Ser/Thr) and 3435C/T (no …