Acetaminophen (APAP) overdose is a common cause of acute liver failure, and beta‐
blockers are commonly used drugs in clinical practice. This study aimed to evaluate the …

Hepatotoxicity induced by acetaminophen (APAP)‐overdose is a major concern in clinical
practice. In the present work, the detoxifying effect of irbesartan (Irb) on the APAP‐induced …

Background Exposure to chemotherapeutic agents such as acetaminophen may lead to
serious liver injury. Calcium deregulation, angiotensin II production and xanthine oxidase …

There is a current need for new therapeutic options for acetaminophen (APAP)-induced
hepatotoxicity. Herein, we assessed the effects of prophylactic and therapeutic treatment …

Acetaminophen (APAP) hepatotoxicity is a serious public health problem in western
countries. Current treatment options for APAP poisoning are limited and novel therapeutic …

The present study aimed to investigate the effect of simvastatin on acetaminophen (APAP)
hepatotoxicity in a mouse model. Male C57BL/6 mice were allocated into the following …

Abstract Acetaminophen (paracetamol, N-acetyl-p-aminophenol; APAP) is a widely used
analgesic/antipyretic drug with few adverse effects at therapeutic doses; suicidal or …

AIM: To examine the effects of 2, 4-dihydroxybenzophenone (BP-1), a benzophenone
derivative used as an ultraviolet light absorbent, on acetaminophen (APAP)-induced …

An overdose of acetaminophen (APAP) causes liver injury in experimental animals and
humans. The activation step (formation of reactive metabolite, N‐acetyl‐p‐benzoquinone …

The hepatotoxicity induced by APAP is caused by the excessive production of N-acetyl-para-
benzoquinone imine (NAPQI), which, when reacting with hepatic proteins proved to cause …