4-Hydroxyisophthalic acid from Decalepis hamiltonii rescues the neurobehavioral deficit in transgenic Drosophila model of taupathies

M Haddadi, SR Jahromi, U Nongthomba… - Neurochemistry …, 2016 - Elsevier
Oxidative stress is one of the major etiological factors implicated in pathogenesis of
neurodegenerative diseases. Since neurons are more sensitive to oxidative damage there is …

Convolvulus pluricaulis (Shankhapushpi) ameliorates human microtubule-associated protein tau (hMAPτ) induced neurotoxicity in Alzheimer's disease Drosophila …

S Olakkaran, A Antony - Journal of chemical neuroanatomy, 2019 - Elsevier
Convolvulus pluricaulis (Shankhapushpi) has long been used as traditional herbal medicine
in India as nerve tonic. We studied the neuroprotective effects of C. pluricaulis extract …

Neurotherapeutic effect of Hyptis spp. leaf extracts in Caenorhabditis elegans models of tauopathy and polyglutamine disease: Role of the glutathione redox cycle

D Vilasboas-Campos, MD Costa… - Free Radical Biology …, 2021 - Elsevier
Hyptis suaveolens (HS), Hyptis pectinata (HP) and Hyptis marrubioides (HM) are plants
used in folk medicine for treatment of several diseases. Here, we tested the in vivo …

Neuroprotective action of 4-Hydroxyisophthalic acid against paraquat-induced motor impairment involves amelioration of mitochondrial damage and …

S Niveditha, T Shivanandappa - Neurotoxicology, 2018 - Elsevier
Neurodegenerative disorders including Parkinson's disease (PD) are believed to be caused
by oxidative stress and mitochondrial dysfunction. Exposure to environmental agents such …

Attenuation of neuromotor deficits by natural antioxidants of Decalepis hamiltonii in transgenic Drosophila model of Parkinson's disease

SR Jahromi, M Haddadi, T Shivanandappa… - Neuroscience, 2015 - Elsevier
Oxidative stress is believed to be a major factor for the onset of Parkinson's disease (PD). In
this study, we have investigated oxidative status in transgenic Drosophila model of PD. Our …

Ameliorative potential of natural antioxidants against paraquat-induced oxidative stress and locomotor impairment in Drosophila melanogaster: A comparative study

S Niveditha, T Shivanandappa… - The Open Bioactive …, 2017 - benthamopen.com
Background: Natural antioxidants show neuroprotective potential to protect against
neurodegenerative disorders in experimental animals. There is a need to characterize …

Jatamansinol from Nardostachys jatamansi Ameliorates Tau-Induced Neurotoxicity in Drosophila Alzheimer's Disease Model

KP Anupama, A Antony, O Shilpa, SV Raghu… - Molecular …, 2022 - Springer
Nardostachys jatamansi has long been used to prepare Medhya Rasayana in traditional
Indian Ayurveda medicine to treat neurological disorders and enhance memory …

Potentiation of paraquat toxicity by inhibition of the antioxidant defenses and protective effect of the natural antioxidant, 4-hydroxyisopthalic acid in Drosophila …

S Niveditha, T Shivanandappa - … and Physiology Part C: Toxicology & …, 2022 - Elsevier
Exposure to pesticides such as paraquat (PQ) is known to induce oxidative stress-mediated
damage, which is implicated in neurodegenerative diseases. The antioxidant enzymes are …

[HTML][HTML] Oolonghomobisflavans exert neuroprotective activities in cultured neuronal cells and anti-aging effects in Caenorhabditis elegans

S Zhang, C Duangjan, T Tencomnao, L Wu… - Frontiers in Aging …, 2022 - frontiersin.org
Potential health benefits of tea has attracted significant scientific and public attention
worldwide. Tea polyphenols are considered as natural promising complementary …

Decalepis hamiltonii root extract attenuates the age-related decline in the cognitive function in Drosophila melanogaster

M Haddadi, SR Jahromi, T Shivanandappa… - Behavioural brain …, 2013 - Elsevier
Age-associated accumulation of oxidative damage linked to decline of antioxidant defense
mechanism, leads to impairment of cognitive function in many organisms. These damages …