Tricyclic antidepressants, as doxepin hydrochloride (DH), may have analgesic local effect
due to its biochemical mechanism of action. Delivery of DH directly to the oral cavity could …

Aim: Doxepin is a traditional tricyclic antidepressant with analgesic and anesthetic
properties when applied topically to the mucosa. Doxepin is one approach in treating …

The objective of the present study was to optimize and evaluate a buccal mucoadhesive
tenoxicam (TNX) local delivery system for the treatment of chronic periodontitis. Full 3 2 …

This study describes the development of semisolid formulations containing doxepin (DOX)
for pain relief in oral mucositis, frequently related to chemotherapy and/or radiotherapy …

In the present investigation, polysaccharide from the Okra fruits (Hibiscus esculentus) was
extracted, characterized and explored for its mucoadhesive potential. Mucoadhesive films of …

Purpose Therapeutic efficacy of zolmitriptan in oral therapy is primarily limited by the
biopharmaceutical issues. The objective of this study is to design and optimize chitosan …

Chitosan (CH) was used as a biocompatible and bioadhesive polymer material to prepare
solid dispersions as well as hydrogels loaded with dexamethasone sodium phosphate …

Within the oral mucosal cavity, the buccal region offers an attractive route of administration
for systemic drug delivery. Pimozide patches were prepared using HPMC (15 & 47 cPs) …

The zolmitriptan is a serotonin (5-HT1) agonist used for the treatment of migraine with or
without aura. The absolute oral bioavailability is about 40 to 50%. The half-life of zolmitriptan …

Oral lichen planus (OLP) is an ongoing and chronic inflammatory disease affecting the
mucous membrane of the oral cavity. Currently, the treatment of choice consists in the direct …