Highlights•Cellular senescence is a key cellular stress response pathway.•Senescent cells
produce various bioactive factors referred to collectively as the SASP.•The cGAS-STING …

Cellular senescence is triggered by various distinct stresses and characterized by a
permanent cell cycle arrest. Senescent cells secrete a variety of inflammatory factors …

Cellular senescence is a natural barrier to tumorigenesis and it contributes to the antitumor
effects of several therapies, including radiation and chemotherapeutic drugs. Senescence …

Aging is associated with an increased incidence of autoimmune diseases, despite the
progressive decline of immune responses (immunosenescence). This apparent paradox can …

Cellular senescence, a cell-autonomous growth arrest program, also executes pleiotropic
non-cell-autonomous activities through the senescence-associated secretory phenotype …

Defective DNA damage response (DDR) signaling is a common mechanism that initiates
and maintains the cellular senescence phenotype. Dysfunctional telomeres activate DDR …

Cellular senescence is a stable cell growth arrest. Senescent cells are metabolically active,
as exemplified by the secretion of inflammatory cytokines, chemokines, and growth factors …

Cellular senescence is historically regarded as a tumor suppression mechanism to prevent
damaged cells from aberrant proliferation in benign and premalignant tumors. However …

Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is
essential for cellular senescence. cGAS promotes inflammatory senescence-associated …

Aging is the consequence of a lifelong accumulation of stochastic damage to tissues and
cellular components. Advancing age closely associates with elevated markers of innate …