We have cloned and sequenced PAS7, a gene required for peroxisome assembly in the
yeast Pichia pastoris. The product of this gene, Pas7p, is a member of the C3HC4 …

Peroxisomes are organelles that carry out diverse biochemical processes in eukaryotic cells,
including the core pathways of β-oxidation of lipid molecules and detoxification of reactive …

Pex18p and Pex21p are structurally related yeast peroxins (proteins required for
peroxisome biogenesis) that are partially redundant in function. One or the other is essential …

Peroxisomes require the translocation of folded and functional target proteins of various
sizes across the peroxisomal membrane. We have investigated the structure and function of …

Pex11p (formerly Pmp27) has been implicated in peroxisomal proliferation (Erdmann, R.,
and G. Blobel. 1995. J. Cell Biol. 128; 509-523; Marshall, PA, YI Krimkevich, RH Lark, JM …

Zellweger syndrome and related disorders represent a group of lethal, genetically
heterogeneous diseases. These peroxisome biogenesis disorders (PBDs) are characterized …

Pex19p is a protein required for the early stages of peroxisome biogenesis, but its precise
function and site of action are unknown. We tested the interaction between Pex19p and all …

Further experimental testing of this model is essential, especially of the biogenesis of well-
characterized integral membrane proteins, for which only limited information is presently …

Peroxisomal matrix protein import requires PEX12, an integral peroxisomal membrane
protein with a zinc ring domain at its carboxy terminus. Mutations in human PEX12 result in …

More than half a century of research on peroxisomes has revealed unique features of this
ubiquitous subcellular organelle, which have often been in disagreement with existing …