▪ Abstract This review summarizes the progress made in our understanding of peroxisome
biogenesis in the last few years, during which the functional roles of many of the 23 peroxins …

The purpose of this review is to bring together and reflect upon recent experimental results
concerning the molecular mechanisms underlying the biogenesis of peroxisomes and other …

Import of peroxisomal matrix proteins is essential for peroxisome biogenesis. Genetic and
biochemical studies using a variety of different model systems have led to the discovery of …

Transcriptome profiling identified the gene PEX25 encoding Pex25p, a peroxisomal
membrane peroxin required for the regulation of peroxisome size and maintenance in …

Eukaryotic cells divide their metabolic labor between functionally distinct, membrane-
enveloped organelles, each precisely tailored for a specific set of biochemical reactions …

In eukaryotic cells, the trafficking of proteins to membrane-bound subcellular compartments,
such as the endoplasmic reticulum (ER), I Golgi complex, lysosomes or vacuoles …

Recent studies on the sorting of peroxisomal membrane proteins challenge the long-
standing model in which peroxisomes are considered to be autonomous organelles that …

Peroxisomes contribute to several crucial metabolic processes such as β-oxidation of fatty
acids, biosynthesis of ether phospholipids and metabolism of reactive oxygen species …

The endoplasmic reticulum (ER) is required for the de novo biogenesis of peroxisomes in
mammalian cells. However, its role in peroxisome maintenance is unclear. To explore ER …

Looks can be deceiving. Although peroxisomes appear to be simple organelles, their
formation and maintenance pose unique challenges for the cell. The birth of new …