The body-brain axis is emerging as a principal conductor of organismal physiology. It
senses and controls organ function1, 2, metabolism3 and nutritional state4-6. Here, we …

Discoveries leading to an improved understanding of immune surveillance of the central
nervous system (CNS) have repeatedly provoked dismissal of the existence of immune …

Whereas the study of the interactions between the immune system and the central nervous
system (CNS) has often focused on pathological conditions, the importance of neuroimmune …

Recent evidence implicates cranial border immune compartments in the meninges, choroid
plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and …

Maintenance of mammalian tissue homeostasis and function requires coordinated actions of
multiple cellular and molecular networks. This complexity is reflected in the immune system …

Neuroimmunology is concerned with the relations between the central nervous and immune
systems and with the mechanisms that drive those relations. The blood-brain barrier (BBB) …

Immune cells rely on cell-cell communication to specify and fine-tune their responses. They
express an extensive network of cell communication modes, including a vast repertoire of …

Communication between the central nervous and immune systems lies at the heart of the
neuroimmune axis. We trace here some of the major conceptual hurtles which were raised …

The 'immune privilege'of the central nervous system (CNS) is indispensable for damage
limitation during inflammation in a sensitive organ with poor regenerative capacity. It is a …

Brain function requires tight regulation of the cerebral microenvironment, an outcome
achieved through specialized brain barriers. The presence of these barriers and the …