Transforming the understanding of brain immunity
Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
Neuroimmune axes of the blood–brain barriers and blood–brain interfaces: bases for physiological regulation, disease states, and pharmacological interventions
MA Erickson, WA Banks - Pharmacological reviews, 2018 - ASPET
Central nervous system (CNS) barriers predominantly mediate the immune-privileged status
of the brain, and are also important regulators of neuroimmune communication. It is …
of the brain, and are also important regulators of neuroimmune communication. It is …
Immune cell compartmentalization for brain surveillance and protection
For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …
T cells become licensed in the lung to enter the central nervous system
F Odoardi, C Sie, K Streyl, VK Ulaganathan… - Nature, 2012 - nature.com
The blood–brain barrier (BBB) and the environment of the central nervous system (CNS)
guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple …
guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple …
Neuroimmune interactions in peripheral organs
Interactions between the nervous and immune systems were recognized long ago, but
recent studies show that this crosstalk occurs more frequently than was previously …
recent studies show that this crosstalk occurs more frequently than was previously …
Immune cells and CNS physiology: Microglia and beyond
GT Norris, J Kipnis - Journal of experimental medicine, 2019 - rupress.org
Recent advances have directed our knowledge of the immune system from a narrative of
“self” versus “nonself” to one in which immune function is critical for homeostasis of organs …
“self” versus “nonself” to one in which immune function is critical for homeostasis of organs …
Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration
H Neumann, H Wekerle - Journal of neuropathology and …, 1998 - search.proquest.com
The immune system and the nervous system are both designed to interact with the body's
environment and to perceive and respond to physical or chemical stimuli gen—erated within …
environment and to perceive and respond to physical or chemical stimuli gen—erated within …
Multifaceted interactions between adaptive immunity and the central nervous system
J Kipnis - Science, 2016 - science.org
Neuroimmunologists seek to understand the interactions between the central nervous
system (CNS) and the immune system, both under homeostatic conditions and in diseases …
system (CNS) and the immune system, both under homeostatic conditions and in diseases …
Structural and functional features of central nervous system lymphatic vessels
One of the characteristics of the central nervous system is the lack of a classical lymphatic
drainage system. Although it is now accepted that the central nervous system undergoes …
drainage system. Although it is now accepted that the central nervous system undergoes …
Central nervous system zoning: how brain barriers establish subdivisions for CNS immune privilege and immune surveillance
ST Proulx, B Engelhardt - Journal of internal medicine, 2022 - Wiley Online Library
The central nervous system (CNS) coordinates all our body functions. Neurons in the CNS
parenchyma achieve this computational task by high speed communication via electrical …
parenchyma achieve this computational task by high speed communication via electrical …