Transforming the understanding of brain immunity

G Castellani, T Croese, JM Peralta Ramos, M Schwartz - Science, 2023 - science.org
Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …

Neuroimmune axes of the blood–brain barriers and blood–brain interfaces: bases for physiological regulation, disease states, and pharmacological interventions

MA Erickson, WA Banks - Pharmacological reviews, 2018 - ASPET
Central nervous system (CNS) barriers predominantly mediate the immune-privileged status
of the brain, and are also important regulators of neuroimmune communication. It is …

Immune cell compartmentalization for brain surveillance and protection

T Croese, G Castellani, M Schwartz - Nature immunology, 2021 - nature.com
For decades, it was commonly accepted that the brain is secluded from peripheral immune
activity and is self-sufficient for its maintenance and repair. This simplistic perception was …

T cells become licensed in the lung to enter the central nervous system

F Odoardi, C Sie, K Streyl, VK Ulaganathan… - Nature, 2012 - nature.com
The blood–brain barrier (BBB) and the environment of the central nervous system (CNS)
guard the nervous tissue from peripheral immune cells. In the autoimmune disease multiple …

Neuroimmune interactions in peripheral organs

RGJ Klein Wolterink, GS Wu, IM Chiu… - Annual review of …, 2022 - annualreviews.org
Interactions between the nervous and immune systems were recognized long ago, but
recent studies show that this crosstalk occurs more frequently than was previously …

Immune cells and CNS physiology: Microglia and beyond

GT Norris, J Kipnis - Journal of experimental medicine, 2019 - rupress.org
Recent advances have directed our knowledge of the immune system from a narrative of
“self” versus “nonself” to one in which immune function is critical for homeostasis of organs …

Neuronal control of the immune response in the central nervous system: linking brain immunity to neurodegeneration

H Neumann, H Wekerle - Journal of neuropathology and …, 1998 - search.proquest.com
The immune system and the nervous system are both designed to interact with the body's
environment and to perceive and respond to physical or chemical stimuli gen—erated within …

Multifaceted interactions between adaptive immunity and the central nervous system

J Kipnis - Science, 2016 - science.org
Neuroimmunologists seek to understand the interactions between the central nervous
system (CNS) and the immune system, both under homeostatic conditions and in diseases …

Structural and functional features of central nervous system lymphatic vessels

A Louveau, I Smirnov, TJ Keyes, JD Eccles… - Nature, 2015 - nature.com
One of the characteristics of the central nervous system is the lack of a classical lymphatic
drainage system. Although it is now accepted that the central nervous system undergoes …

Central nervous system zoning: how brain barriers establish subdivisions for CNS immune privilege and immune surveillance

ST Proulx, B Engelhardt - Journal of internal medicine, 2022 - Wiley Online Library
The central nervous system (CNS) coordinates all our body functions. Neurons in the CNS
parenchyma achieve this computational task by high speed communication via electrical …