The spatiotemporal regulation of inflammasome activation remains unclear. To examine the
mechanism underlying the assembly and regulation of the inflammasome response, here …

Chronic inflammation is a risk factor for many types of human cancers, yet the precise
mechanism of this strong association is largely unknown. The inflammasome is a …

Chronic inflammation is a known risk factor for tumorigenesis, yet the precise mechanism of
this association is currently unknown. The inflammasome, a multiprotein complex formed by …

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the world.
Inflammation is often an underlying risk factor for developing CRC. Maintaining gut …

NFAT transcription factors control T-cell activation and function. Specifically, the transcription
factor NFATc2 affects the regulation of cell differentiation and growth and plays a critical role …

Chronic inflammation has been implicated in the etiology of colorectal adenoma and cancer;
however, few key inflammatory genes mediating this relationship have been identified. In …

Inflammasomes are large intracellular multi-protein signalling complexes that are formed in
the cytosolic compartment as an inflammatory immune response to endogenous danger …

The caspase activation and recruitment domain (CARD)-based inflammasome sensors
NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the …

The activation of specific cytosolic pathogen recognition receptors, the nucleotide‐binding‐
oligomerization‐domain‐(NOD‐) like receptors (NLRs), leads to the assembly of the …

Colorectal cancer is a leading cause of cancer-related deaths worldwide. Chronic
inflammation is recognized as a predisposing factor for the development of colon cancer, but …