La proteína recombinante 1-desoxi-D-xilulosa 5-fosfato reductoisomerasa apicoplastídica de Plasmodium falciparum y su interacción con aptámeros
S Manresa Guille - 2020 - dspace.uvic.cat
La especie humana se ve gravemente afectada por la enfermedad de la malaria, que es
una infección parasitaria causada por cinco especies distintas de Plasmodium, de las …
una infección parasitaria causada por cinco especies distintas de Plasmodium, de las …
Enzymes of Isoprenoid Biosynthesis and Control of Malarial Parasite Plasmodium falciparum
There is high importance for the control of parasite Plasmodium falciparum which is
responsible for causing malaria. Following the classical mevalonate pathway, the metabolite …
responsible for causing malaria. Following the classical mevalonate pathway, the metabolite …
The druggable antimalarial target PfDXR: overproduction strategies and kinetic characterization
JL Goble, H Johnson, J De Ridder… - Protein and Peptide …, 2013 - ingentaconnect.com
Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR) is a
key enzyme in the synthesis of isoprenoids in the malaria parasite, using a pathway that is …
key enzyme in the synthesis of isoprenoids in the malaria parasite, using a pathway that is …
[HTML][HTML] Selection of an Aptamer against the Enzyme 1-deoxy-D-xylulose-5-phosphate Reductoisomerase from Plasmodium falciparum
The methyl erythritol phosphate (MEP) pathway of isoprenoid biosynthesis is essential for
malaria parasites and also for several human pathogenic bacteria, thus representing an …
malaria parasites and also for several human pathogenic bacteria, thus representing an …
Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene
AR Odom, WC Van Voorhis - Molecular and biochemical parasitology, 2010 - Elsevier
Novel antimalarial drugs are urgently needed to treat severe malaria caused by Plasmodium
falciparum. Isoprenoid biosynthesis is a promising target pathway, since the biosynthetic …
falciparum. Isoprenoid biosynthesis is a promising target pathway, since the biosynthetic …
[HTML][HTML] New Insight into Isoprenoids Biosynthesis Process and Future Prospects for Drug Designing in Plasmodium
The MEP (Methyl Erythritol Phosphate) isoprenoids biosynthesis pathway is an attractive
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …
drug target to combat malaria, due to its uniqueness and indispensability for the parasite. It …
Binding modes of reverse fosmidomycin analogs toward the antimalarial target IspC
S Konzuch, T Umeda, J Held, S Hähn… - Journal of medicinal …, 2014 - ACS Publications
1-Deoxy-d-xylulose 5-phosphate reductoisomerase of Plasmodium falciparum (Pf IspC, Pf
Dxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of isoprenoid …
Dxr), believed to be the rate-limiting enzyme of the nonmevalonate pathway of isoprenoid …
A chemical rescue screen identifies a Plasmodium falciparum apicoplast inhibitor targeting MEP isoprenoid precursor biosynthesis
W Wu, Z Herrera, D Ebert, K Baska… - Antimicrobial agents …, 2015 - Am Soc Microbiol
The apicoplast is an essential plastid organelle found in Plasmodium parasites which
contains several clinically validated antimalarial-drug targets. A chemical rescue screen …
contains several clinically validated antimalarial-drug targets. A chemical rescue screen …
Inhibition of the non-Mevalonate Isoprenoid pathway by reverse Hydroxamate analogues of Fosmidomycin
C Lienau, S Konzuch, T Gräwert, B Illarionov… - Procedia …, 2015 - Elsevier
The non-mevalonate (methylerythritol phosphate, MEP) pathway for isoprenoid biosynthesis
is essential in Plasmodium spp.., but is absent in the human host. The pathway is a clinically …
is essential in Plasmodium spp.., but is absent in the human host. The pathway is a clinically …
[HTML][HTML] Effect of fosmidomycin on metabolic and transcript profiles of the methylerythritol phosphate pathway in Plasmodium falciparum
MB Cassera, EF Merino, VJ Peres… - Memórias do Instituto …, 2007 - SciELO Brasil
In Plasmodium falciparum, the formation of isopentenyl diphosphate and dimethylallyl
diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the …
diphosphate, central intermediates in the biosynthesis of isoprenoids, occurs via the …