[PDF][PDF] Inhibiting Plasmodium Falciparum IspD, a MEP Pathway Enzyme, as a Novel Target for the Development of Antimalarial Chemotherapeutics
MJ Pye - 2017 - core.ac.uk
Malaria remains one of the world's most widespread and deadly parasitic diseases, killing
hundreds of thousands of people per year, most of whom are children under the age of 5 …
hundreds of thousands of people per year, most of whom are children under the age of 5 …
[引用][C] Synthesis and Biolgical Screening of Potential Plasmodium Falciparum DXR Inhibitors
CM Adeyemi - 2016 - Ph. D. Thesis, Rhodes University …
[HTML][HTML] Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum
FM Jordão, EA Kimura, AM Katzin - Memorias do Instituto Oswaldo …, 2011 - SciELO Brasil
The development of new drugs is one strategy for malaria control. Biochemical pathways
localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are …
localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are …
Fosmidomycin as an antimalarial agent
J Wiesner, A Reichenberg, M Hintz, R Ortmann… - Isoprenoid Synthesis in …, 2013 - Springer
The isoprenoid biosynthesis of Plasmodium falciparum, the causative agent of malignant
tertiana malaria, solely depends on the mevalonate-independent 2-C-methyl-d-erythritol 4 …
tertiana malaria, solely depends on the mevalonate-independent 2-C-methyl-d-erythritol 4 …
Retracted: Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum
BR International - Biochemistry Research International, 2022 - ncbi.nlm.nih.gov
[1] T. Qidwai, F. Jamal, MY Khan, and B. Sharma,“Exploring Drug Targets in Isoprenoid
Biosynthetic Pathway for Plasmodium falciparum,” Biochemistry Research International, vol …
Biosynthetic Pathway for Plasmodium falciparum,” Biochemistry Research International, vol …
Plasmodium IspD (2-C-Methyl-d-erythritol 4-Phosphate Cytidyltransferase), an Essential and Druggable Antimalarial Target
LS Imlay, CM Armstrong, MC Masters, T Li… - ACS Infectious …, 2015 - ACS Publications
As resistance to current therapies spreads, novel antimalarials are urgently needed. In this
work, we examine the potential for therapeutic intervention via the targeting of Plasmodium …
work, we examine the potential for therapeutic intervention via the targeting of Plasmodium …
Novel reverse thia-analogs of fosmidomycin: Synthesis and antiplasmodial activity
C Lienau, T Gräwert, LAA Avelar, B Illarionov… - European Journal of …, 2019 - Elsevier
Thia analogs of fosmidomycin are potent inhibitors of the non-mevalonate isoprenoid
biosynthesis enzyme 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC, Dxr) of …
biosynthesis enzyme 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC, Dxr) of …
Mechanism of Action of N-Acyl and N-Alkoxy Fosmidomycin Analogs: Mono- and Bisubstrate Inhibition of IspC from Plasmodium falciparum, a Causative Agent of …
MB Girma, HS Ball, X Wang, RC Brothers… - ACS …, 2021 - ACS Publications
Malaria is a global health threat that requires immediate attention. Malaria is caused by the
protozoan parasite Plasmodium, the most severe form of which is Plasmodium falciparum …
protozoan parasite Plasmodium, the most severe form of which is Plasmodium falciparum …
Isoprenoid biosynthesis in Plasmodium falciparum
AM Guggisberg, RE Amthor, AR Odom - Eukaryotic cell, 2014 - Am Soc Microbiol
Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium
falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via …
falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via …
[PDF][PDF] Crystal structures of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Plasmodium falciparum complexed with fosmidomycin analogs
T Umeda, Y Kusakabe, Y Sakamoto, Y Odanaka… - Phot. Fact. Act …, 2015 - pfwww.kek.jp
2 Experiment Expression and purification of PfDXR were performed as previously described
[1]. PfDXR inhibitors used for crystallographic analyses were α-aryl-substituted …
[1]. PfDXR inhibitors used for crystallographic analyses were α-aryl-substituted …