Malaria remains one of the world's most widespread and deadly parasitic diseases, killing
hundreds of thousands of people per year, most of whom are children under the age of 5 …

The development of new drugs is one strategy for malaria control. Biochemical pathways
localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are …

The isoprenoid biosynthesis of Plasmodium falciparum, the causative agent of malignant
tertiana malaria, solely depends on the mevalonate-independent 2-C-methyl-d-erythritol 4 …

[1] T. Qidwai, F. Jamal, MY Khan, and B. Sharma,“Exploring Drug Targets in Isoprenoid
Biosynthetic Pathway for Plasmodium falciparum,” Biochemistry Research International, vol …

As resistance to current therapies spreads, novel antimalarials are urgently needed. In this
work, we examine the potential for therapeutic intervention via the targeting of Plasmodium …

Thia analogs of fosmidomycin are potent inhibitors of the non-mevalonate isoprenoid
biosynthesis enzyme 1-deoxy-d-xylulose 5-phosphate reductoisomerase (IspC, Dxr) of …

Malaria is a global health threat that requires immediate attention. Malaria is caused by the
protozoan parasite Plasmodium, the most severe form of which is Plasmodium falciparum …

Malaria kills nearly 1 million people each year, and the protozoan parasite Plasmodium
falciparum has become increasingly resistant to current therapies. Isoprenoid synthesis via …

2 Experiment Expression and purification of PfDXR were performed as previously described
[1]. PfDXR inhibitors used for crystallographic analyses were α-aryl-substituted …