Type II fatty acid biosynthesis, a new approach in antimalarial natural product discovery
D Tasdemir - Phytochemistry Reviews, 2006 - Springer
Malaria, one of the most problematic infectious diseases worldwide, is on the rise. The
absence of an effective vaccine and the spread of drug-resistant strains of Plasmodium …
absence of an effective vaccine and the spread of drug-resistant strains of Plasmodium …
The isoprenoid-precursor dependence of Plasmodium spp.
JY van der Meer, AKH Hirsch - Natural product reports, 2012 - pubs.rsc.org
Covering: up to March 2012 Due to the increase in resistance of Plasmodium spp. against
available antimalarials, there is a need for new, effective and innovative drugs. The non …
available antimalarials, there is a need for new, effective and innovative drugs. The non …
Crystal Structure of 1-Deoxy-D-xylulose 5-phosphate Reductoisomerase Complexed with Cofactors:-Implications of a Flexible Loop Movement upon Substrate …
S Yajima, T Nonaka, T Kuzuyama… - The journal of …, 2002 - academic.oup.com
The key enzyme in the nonmevalonate pathway, 1-deoxy-D-xylulose 5-phosphate
reductoisomerase (DXR), has been shown to be an effective target of antimalarial drugs …
reductoisomerase (DXR), has been shown to be an effective target of antimalarial drugs …
The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites
M Okada, PA Sigala - PLoS Pathogens, 2023 - journals.plos.org
Isoprenoid precursor synthesis is an ancient and fundamental function of plastid organelles
and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [–]. Over …
and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [–]. Over …
A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites
Isoprenoid biosynthesis through the methylerythritol phosphate (MEP) pathway generates
commercially important products and is a target for antimicrobial drug development. MEP …
commercially important products and is a target for antimicrobial drug development. MEP …
Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure–activity studies
ZK Yao, PM Krai, EF Merino, ME Simpson… - Bioorganic & medicinal …, 2015 - Elsevier
Compounds that target isoprenoid biosynthesis in Plasmodium falciparum could be a
welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) …
welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) …
[图书][B] MEPicides: Design, Synthesis, and Evaluation of Novel Antimalarials
KM Heidel - 2021 - search.proquest.com
Malaria, an ancient disease caused by Plasmodium parasites, continues to be one of the
most severe infectious diseases worldwide. Traditional therapies are rapidly succumbing to …
most severe infectious diseases worldwide. Traditional therapies are rapidly succumbing to …
Plasmodium falciparum: new molecular targets with potential for antimalarial drug development
DL Gardiner, TS Skinner-Adams… - Expert review of anti …, 2009 - Taylor & Francis
Malaria remains one of the world's most devastating infectious diseases. Drug resistance to
all classes of antimalarial agents has now been observed, highlighting the need for new …
all classes of antimalarial agents has now been observed, highlighting the need for new …
Cloning and characterization of bifunctional enzyme farnesyl diphosphate/geranylgeranyl diphosphate synthase from Plasmodium falciparum
Background Isoprenoids are the most diverse and abundant group of natural products. In
Plasmodium falciparum, isoprenoid synthesis proceeds through the methyl erythritol …
Plasmodium falciparum, isoprenoid synthesis proceeds through the methyl erythritol …
NOVEL ANTIMALARIAL AGENTS AND TARGETS: AN OPTIMISM OVER RESISTANCE.
P Jain, DS Bele - International Journal of Pharmaceutical …, 2015 - search.ebscohost.com
Malaria is a complex disease with ample of host-parasite interactions. Due to long terminal
elimination half-life, a shallow concentration-effect relationship, and mutations a drug …
elimination half-life, a shallow concentration-effect relationship, and mutations a drug …