Malaria, one of the most problematic infectious diseases worldwide, is on the rise. The
absence of an effective vaccine and the spread of drug-resistant strains of Plasmodium …

Covering: up to March 2012 Due to the increase in resistance of Plasmodium spp. against
available antimalarials, there is a need for new, effective and innovative drugs. The non …

The key enzyme in the nonmevalonate pathway, 1-deoxy-D-xylulose 5-phosphate
reductoisomerase (DXR), has been shown to be an effective target of antimalarial drugs …

Isoprenoid precursor synthesis is an ancient and fundamental function of plastid organelles
and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [–]. Over …

Isoprenoid biosynthesis through the methylerythritol phosphate (MEP) pathway generates
commercially important products and is a target for antimicrobial drug development. MEP …

Compounds that target isoprenoid biosynthesis in Plasmodium falciparum could be a
welcome addition to malaria chemotherapy, since the methylerythritol phosphate (MEP) …

Malaria, an ancient disease caused by Plasmodium parasites, continues to be one of the
most severe infectious diseases worldwide. Traditional therapies are rapidly succumbing to …

Malaria remains one of the world's most devastating infectious diseases. Drug resistance to
all classes of antimalarial agents has now been observed, highlighting the need for new …

Background Isoprenoids are the most diverse and abundant group of natural products. In
Plasmodium falciparum, isoprenoid synthesis proceeds through the methyl erythritol …

Malaria is a complex disease with ample of host-parasite interactions. Due to long terminal
elimination half-life, a shallow concentration-effect relationship, and mutations a drug …