Plasmodium falciparum 1-deoxy-d-xylulose-5-phosphate reductoisomerase (Pf-DXR) is a
potential target for antimalarial chemotherapy. The three-dimensional model (3D) of this …

Theileria). It has recently been shown1 that these parasites have acquired a non-
photosynthetic plastid, the apicoplast, which contains a circular, 27–35 kb …

Triosephosphate isomerase (TIM), a central enzyme in the glycolytic pathway, has been the
subject of extensive structural and mechanistic investigations over the past 30 years. The …

The methylerythritol phosphate pathway to isoprenoids has been firmly established as an
alternate to the mevalonate pathway in many bacteria, plants, algae, and the malaria …

The 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway for isoprenoid biosynthesis has
come under increased scrutiny as a target for novel antimalarial, antibacterial and herbicidal …

The enzyme d-1-deoxyxylulose-5-phosphate reductoisomerase (DXR, EC1. 1.1. 267)
catalyzes the key isomerization reaction during the biosynthesis of the terpene precursors …

A major supply of energy in the rapidly multiplying intraerythrocytic Plasmodium falciparum
is from the glycolytic pathway. We have isolated the cDNA and genomic clones of the …

Production of recombinant malaria proteins in the methylotrophic yeast Pichia pastoris has
been difficult due to constraints in transcription, translation and/or post-translation controls …

Apicomplexan parasites infectious to humans include Plasmodium spp., Babesia spp.,
Toxoplasma gondii, Cryptosporidium spp., Isospora belli and Cyclospora cayetanensis. With …

Isoprenoids play important roles in all living organisms as components of structural
cholesterol, steroid hormones in mammals, carotenoids in plants, and ubiquinones …