Malaria parasites contain an essential organelle called the apicoplast that houses metabolic
pathways for fatty acid, heme, isoprenoid, and iron–sulfur cluster synthesis. Surprisingly …

Background: Malaria caused by the parasite Plasmodium falciparum is a major public health
concern. The parasite lacks a functional tricarboxylic acid cycle, making glycolysis its sole …

Although there are potent antimalarial drugs available, the spread of drug resistance has led
to an increase in morbidity and mortality rates in malaria-endemic regions. To overcome …

Fusion of the last two enzymes in the pyrimidine biosynthetic pathway in the inversed order
by having a COOH-terminal orotate phosphoribosyltransferase (OPRT) and an NH 2 …

The apicoplast is a recently discovered, plastid-like organelle present in most apicomplexa.
The methylerythritol phosphate (MEP) pathway involved in isoprenoid biosynthesis is one of …

An unusual plastid organelle retaining the basicness of plastid, in apicomplexan parasites
such as Plasmodium named apicoplast was reported (McFadden, Reith, Munholland, & …

There are important challenges when investigating individual post-translational
modifications (PTMs) or protein interaction network and delineating if PTMs or their changes …

Humanity is burdened by malaria as millions are infected with this disease. Although
advancements have been made in the treatment of malaria, optimism regarding our fight …

Highlights•Isoprenoid precursors and CoA are essential metabolites generated by
apicoplast-localized enzymes.•Isoprenoids play an essential role in apicoplast …

In eukaryotes, the formation of protein disulfide bonds among cysteine residues is mediated
by protein disulfide isomerases and occurs in the highly oxidised environment of the …