Although gene fusions have been recognized as important drivers of cancer for decades,
our understanding of the prevalence and function of gene fusions has been revolutionized …

Gene fusions are important genomic events in human cancer because their fusion gene
products can drive the development of cancer and thus are potential prognostic tools or …

Structural chromosome rearrangements may result in the exchange of coding or regulatory
DNA sequences between genes. Many such gene fusions are strong driver mutations in …

Fusion genes are hybrid genes that combine parts of two or more original genes. They can
form as a result of chromosomal rearrangements or abnormal transcription, and have been …

Gene fusion represents a class of molecular aberrations in cancer and has been exploited
for therapeutic purposes. In this paper we describe TumorFusions, a data portal that …

Gene fusion is one of the hallmarks of cancer genome via chromosomal rearrangement
initiated by DNA double-strand breakage. To date, many fusion genes (FGs) have been …

In recent years, gene fusion detection for cancer treatment has become increasingly
important since more therapeutic agents have been developed to suppress fusion kinases …

Gene fusions created by somatic genomic rearrangements are known to play an important
role in the onset and development of some cancers, such as lymphomas and sarcomas …

Transcript fusions as a result of chromosomal rearrangements have been a focus of
attention in cancer as they provide attractive therapeutic targets. To identify novel fusion …

Fusion genes represent a class of attractive therapeutic targets. Thousands of fusion genes
have been identified in patients with cancer, but the functional consequences and …