One-year results from the Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries (GUSTO-I) trial
RM Califf, HD White, F Van de Werf, Z Sadowski… - Circulation, 1996 - Am Heart Assoc
Background In the randomized Global Utilization of t-PA and Streptokinase for Occluded
Coronary Arteries (GUSTO-I) trial, 41 021 patients received one of four thrombolytic …
Coronary Arteries (GUSTO-I) trial, 41 021 patients received one of four thrombolytic …
Lessons we have learned from the GUSTO trial
DR Holmes Jr, RM Califf, EJ Topol - Journal of the American College of …, 1995 - Elsevier
Thrombolytic therapy remains a mainstay for the treatment of patients with acute myocardial
infarction. This therapy has been the subject of intense investigation and multiple studies as …
infarction. This therapy has been the subject of intense investigation and multiple studies as …
Link between the angiographic substudy and mortality outcomes in a large randomized trial of myocardial reperfusion: importance of early and complete infarct artery …
RJ Simes, EJ Topol, DR Holmes Jr, HD White… - Circulation, 1995 - Am Heart Assoc
Background The Global Utilization of Streptokinase and TPA for Occluded Coronary Arteries
(GUSTO-I) trial was designed to test whether thrombolytic strategies achieving more …
(GUSTO-I) trial was designed to test whether thrombolytic strategies achieving more …
Long-term mortality of patients with acute myocardial infarction in the United States and Canada: comparison of patients enrolled in Global Utilization of Streptokinase …
P Kaul, PW Armstrong, WC Chang, CD Naylor… - Circulation, 2004 - Am Heart Assoc
Background—In a previous substudy of the GUSTO-I trial, we observed better functional and
quality-of-life outcomes among patients in the United States (US patients) compared with …
quality-of-life outcomes among patients in the United States (US patients) compared with …
Holding GUSTO up to the light
KL Lee, RM Califf, J Simes, F Van de Werf… - Annals of internal …, 1994 - acpjournals.org
The Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded
Coronary Arteries (GUSTO) trial, a recent randomized “megatrial” of thrombolytic therapies …
Coronary Arteries (GUSTO) trial, a recent randomized “megatrial” of thrombolytic therapies …
Survival outcomes 1 year after reperfusion therapy with either alteplase or reteplase for acute myocardial infarction: results from the Global Utilization of Streptokinase …
EJ Topol, EM Ohman, PW Armstrong, R Wilcox… - Circulation, 2000 - Am Heart Assoc
Background—New recombinant plasminogen activators have been developed to simulate
the fibrinolytic action of the physiological serine protease tissue plasminogen activator …
the fibrinolytic action of the physiological serine protease tissue plasminogen activator …
Confronting the issues of patient safety and investigator conflict of interest in an international clinical trial of myocardial reperfusion
EJ Topol, P Armstrong, F Van de Werf… - Journal of the American …, 1992 - Elsevier
Abstract The Global Utilization of Streptokinase and Tissue Plasminogen Activator for
Occluded Coronary Arteries (GUSTO) trial is a large scale international trial of new …
Occluded Coronary Arteries (GUSTO) trial is a large scale international trial of new …
Cost effectiveness of thrombolytic therapy with tissue plasminogen activator as compared with streptokinase for acute myocardial infarction
DB Mark, MA Hlatky, RM Califf, CD Naylor… - New England journal …, 1995 - Mass Medical Soc
Background Patients with acute myocardial infarction who were treated with accelerated
tissue plasminogen activator (t-PA)(given over a period of 11/2 hours rather than the …
tissue plasminogen activator (t-PA)(given over a period of 11/2 hours rather than the …
Multicenter patency trial of intravenous anistreplase compared with streptokinase in acute myocardial infarction. The TEAM-2 Study Investigators.
JL Anderson, SG Sorensen, FL Moreno… - Circulation, 1991 - Am Heart Assoc
Thrombolytic therapy has been shown to improve clinical outcome when administered early
after the onset of symptoms of acute myocardial infarction; the mechanism of benefit is …
after the onset of symptoms of acute myocardial infarction; the mechanism of benefit is …
Prediction of 1-year survival after thrombolysis for acute myocardial infarction in the global utilization of streptokinase and TPA for occluded coronary arteries trial
RM Califf, KS Pieper, KL Lee, F Van de Werf… - Circulation, 2000 - Am Heart Assoc
Background—When a patient survives thrombolysis for acute myocardial infarction, little
information from large studies exists from which to estimate prognosis during follow-up visits …
information from large studies exists from which to estimate prognosis during follow-up visits …