Juliflorine: a potent natural peripheral anionic-site-binding inhibitor of acetylcholinesterase with calcium-channel blocking potential, a leading candidate for …

MI Choudhary, SA Nawaz, MK Azim, MN Ghayur… - Biochemical and …, 2005 - Elsevier
The alkaloid juliflorine (1) from Prosopis juliflora inhibited acetylcholinesterase (AChE, EC
3.1. 1.7) and butyrylcholinesterase (BChE, EC 3.1. 1.8) enzymes in a concentration …

Cholinesterase inhibitors assessment of aporphine alkaloids from Annona crassiflora and molecular docking studies

MF Barbosa, AB Justino, MM Martins, KRA Belaz… - Bioorganic …, 2022 - Elsevier
Annona crassiflora Mart. is an endemic plant from Brazilian Cerrado (savanna) biome,
commonly employed in traditional medicine to treat wounds, diarrhea, and scalp infections …

Synthesis and cholinesterase inhibition of cativic acid derivatives

NP Alza, V Richmond, CJ Baier, E Freire… - Bioorganic & medicinal …, 2014 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder associated with memory
impairment and cognitive deficit. Most of the drugs currently available for the treatment of AD …

Neurologically Potent Molecules from Crataegus oxyacantha; Isolation, Anticholinesterase Inhibition, and Molecular Docking

M Ali, S Muhammad, MR Shah, A Khan… - Frontiers in …, 2017 - frontiersin.org
Crataegus oxyacantha is an important herbal supplement and famous for its antioxidant
potential. The antioxidant in combination with anticholinesterase activity can be considered …

Isolation, identification, and quantification of Pentylcurcumene from Geophila repens: A new class of cholinesterase inhibitor for Alzheimer's disease

UC Dash, S Kanhar, A Dixit, J Dandapat, AK Sahoo - Bioorganic Chemistry, 2019 - Elsevier
The aerial part of Geophila repens (L.) IM Johnst (Rubiaceae) has been used in India to
improve intelligence and memory for a long time. As part of our ongoing efforts in …

In Vitro and in Silico Analysis of Phytochemicals From Fallopia dentatoalata as Dual Functional Cholinesterase Inhibitors for the Treatment of Alzheimer's Disease

Y Wu, X Su, J Lu, M Wu, SY Yang, Y Mai… - Frontiers in …, 2022 - frontiersin.org
Current studies have found that butyrylcholinesterase (BuChE) replaces the biological
function of acetylcholinesterase (AChE) in the late stage of Alzheimer's disease. Species in …

In vitro and in silico acetylcholinesterase inhibitory activity of thalictricavine and canadine and their predicted penetration across the blood-brain barrier

J Chlebek, J Korábečný, R Doležal, Š Štěpánková… - Molecules, 2019 - mdpi.com
In recent studies, several alkaloids acting as cholinesterase inhibitors were isolated from
Corydalis cava (Papaveraceae). Inhibitory activities of (+)-thalictricavine (1) and (+) …

Cholinesterase Inhibition Activity, Alkaloid Profiling and Molecular Docking of Chilean Rhodophiala (Amaryllidaceae)

LR Tallini, J Bastida, N Cortes, EH Osorio, C Theoduloz… - Molecules, 2018 - mdpi.com
Amaryllidaceae plants are the commercial source of galanthamine, an alkaloid approved for
the clinical treatment of Alzheimer's disease. The chemistry and bioactivity of Chilean …

Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure–activity relationships

ZD Yang, DZ Duan, WW Xue, XJ Yao, S Li - Life sciences, 2012 - Elsevier
AIMS: Inhibition of acetylcholinesterase (AChE) is still considered as a strategy for the
treatment of neurological disorders such as Alzheimer's disease (AD). Many plant derived …

Interaction study of two diterpenes, cryptotanshinone and dihydrotanshinone, to human acetylcholinesterase and butyrylcholinesterase by molecular docking and …

KKK Wong, JCK Ngo, S Liu, H Lin, C Hu… - Chemico-biological …, 2010 - Elsevier
Alzhemier's disease (AD) is a common form of dementia in the ageing population which is
characterized by depositions of amyloids and a cholinergic neurotransmission deficit in the …