Objectives: To outline the concepts involved in optimizing antibacterial dosing in critically ill
patients with acute renal failure undergoing continuous renal replacement therapy (CRRT) …

Background: Appropriate antibacterial therapy is important to maximize patient survival in
sepsis. Acute renal failure complicates optimal antibiotic administration. Methods: MEDLINE …

Determining appropriate antibiotic dosing for critically ill patients receiving renal
replacement therapy (RRT) is complex. Worldwide unstandardized and heterogeneous …

Objectives: In critically ill patients receiving continuous renal replacement therapy, we aimed
to assess the variability of antibiotic trough concentrations, the influence of effluent flow rates …

Acute kidney injury represents a common complication in critically ill patients affected by
septic shock and in many cases continuous renal replacement therapy (CRRT) may be …

Published CRRT drug dosing algorithms and other dosing guidelines appear to result in
underdosed antibiotics, leading to failure to attain pharmacodynamic targets. High mortality …

Infectious diseases and impaired renal function often occur in critically ill patients, and
delaying the start of appropriate empiric antimicrobial therapy or starting inappropriate …

Continuous renal replacement therapy (CRRT) is now commonly used as a means of
support for critically ill patients with renal failure. No recent comprehensive guidelines exist …

ABSTRACT A careful management of antimicrobials is essential in the critically ill with acute
kidney injury, especially if renal replacement therapy is required. Acute kidney injury may …

Optimising antimicrobial dosing for critically ill patients is highly challenging and when it is
not achieved can lead to worse patient outcomes. To this end, use of dosing regimens …