The existence of interindividual variations in G protein-coupled receptor sequences has
been recognized early on. Recent advances in large-scale exon sequencing techniques are …

Melatonin is produced during the night and regulates sleep and circadian rhythms. Loss-of-
function variants in MTNR1B, which encodes the melatonin receptor MT2, a G protein …

Abstract Purpose of Review Type 2 diabetes (T2D) is a complex genetic metabolic disorder.
T2D heritability has been estimated around 40–70%. In the last decade, exponential …

Genome-wide association studies have revealed that common noncoding variants in
MTNR1B (encoding melatonin receptor 1B, also known as MT2) increase type 2 diabetes …

Despite considerable advances in the past few years, obesity and type 2 diabetes mellitus
(T2DM) remain two major challenges for public health systems globally. In the past 9 years …

Melatonin is synthesized and secreted mainly by the pineal gland in a circadian fashion, and
it thus mediates endogenous circadian rhythms and influences other physiological functions …

The incidence of type 2 diabetes mellitus has markedly increased worldwide over the past
decades. Pancreatic β-cell dysfunction as well as central and peripheral insulin resistance …

OBJECTIVE Common variants in the melatonin receptor type 1B (MTNR1B) locus have
been shown to increase fasting plasma glucose (FPG) and the risk of type 2 diabetes. The …

Melatonin is a circulating hormone that is mainly released from the pineal gland. It is best
known as a regulator of seasonal and circadian rhythms, its levels being high during the …

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