Targeted degradation of c-Fos, but not v-Fos, by a phosphorylation-dependent signal on c-Jun

AG Papavassiliou, M Treier, C Chavrier, D Bohmann - Science, 1992 - science.org
The proto-oncogene products c-Fos and c-Jun heterodimerize through their leucine zippers
to form the AP-1 transcription factor. The transcriptional activity of the heterodimer is …

Redox regulation of fos and jun DNA-binding activity in vitro

C Abate, L Patel, FJ Rauscher III, T Curran - Science, 1990 - science.org
The proto-oncogenes c-fos and c-jun function cooperatively as inducible transcription factors
in signal transduction processes. Their protein products, Fos and Jun, form a heterodimeric …

Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers

R Turner, R Tjian - Science, 1989 - science.org
The discovery that the AP-1 family of enhancer binding factors includes a complex of the
cellular Fos (cFos) and cellular Jun (cJun) proteins established a direct and important link …

Fos-Associated Protein p39 Is the Product of the jun Proto-Oncogene

FJ Rauscher III, DR Cohen, T Curran, TJ Bos, PK Vogt… - Science, 1988 - science.org
The Fos protein complex and several Fos-related antigens (FRA) bind specifically to a
sequence element referred to as the HeLa cell activator protein 1 (AP-1) binding site. A …

Identification of a Transcriptional Enhancer Element Upstream from the Proto-Oncogene fos

J Deschamps, F Meijlink, IM Verma - Science, 1985 - science.org
Sequences upstream from the proto-oncogene fos were shown to be essential for its
transcription. Transient expression of the chloramphenicol acetyltransferase (CAT) gene …

Human Proto-Oncogene c-jun Encodes a DNA Binding Protein with Structural and Functional Properties of Transcription Factor AP-1

D Bohmann, TJ Bos, A Admon, T Nishimura, PK Vogt… - Science, 1987 - science.org
Nuclear oncogene products have the potential to induce alterations in gene regulation
leading to the genesis of cancer. The biochemical mechanisms by which nuclear …

Role of DNA 5-Methylcytosine Transferase in Cell Transformation by fos

AV Bakin, T Curran - Science, 1999 - science.org
The Fos and Jun oncoproteins form dimeric complexes that stimulate transcription of genes
containing activator protein–1 regulatory elements. We found, by representational difference …

The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose

LC Sambucetti, T Curran - Science, 1986 - science.org
The properties of the viral and cellular fos proteins (Fos) were investigated as a first step
toward understanding the function of the fos gene. Treatment of nuclei with salt and nonionic …

Expression of c-fos Protein in Brain: Metabolic Mapping at the Cellular Level

SM Sagar, FR Sharp, T Curran - Science, 1988 - science.org
The proto-oncogene c-fos is expressed in neurons in response to direct stimulation by
growth factors and neurotransmitters. In order to determine whether the c-fos protein (Fos) …

Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains

R Gentz, FJ Rauscher III, C Abate, T Curran - Science, 1989 - science.org
The protein products of the fos and jun proto-oncogenes form a heterodimeric complex that
participates in a stable high affinity interaction with DNA elements containing AP-1 binding …