The inducible transcriptional complex AP-1, composed of c-Fos and c-Jun proteins, is crucial
for cell adaptation to many environmental changes. While its mechanisms of activation have …

The proto-oncogene-encoded transcription factor c-Jun activates genes in response to a
number of inducers that act through mitogen-activated protein kinase (MAPK) signal …

THE products of the cellular and retroviral fos genes associate with other nuclear proteins1,
2, among them the transcription factor APl/Jun (see ref. 3 for a review). The Fos/Jun complex …

Two forms of FosB transcript and their products can be identified in mouse NIH 3T3 cells
following serum induction. The larger RNA codes for a 338-amino acid protein, whereas the …

The p53 tumor suppressor gene is mutated in over 50% of human cancers, resulting in
inactivation of the wild-type (wt) p53 protein. The most notable biochemical feature of p53 is …

The c-fos gene encodes a basic region-leucine zipper transcription factor that requires
heterodimerization with a member of the Jun family for stable DNA binding. Fos/Jun …

c‐Fos protooncoprotein is a short‐lived transcription factor with oncogenic potential. It is
massively degraded by the proteasome in vivo under various experimental conditions …

NEWS AND) VIEWS Page 1 NEWS AND) VIEWS ported by Drevets et al. Taken together, the
classic studies and the new results of Drevets et al. imply that suppression of competing stimuli …

The mammalian transcription factor AP-2 is a retinoic acid inducible sequence-specific DNA-
binding protein that is developmentally regulated. In this report, the functional domains …

Rapid degradation of c-fos proto-oncogene mRNA is crucial for transient c-fos gene
expression. Experiments were performed to investigate the cellular mechanisms responsible …