Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the
progression of Alzheimer's disease (AD). Since BDNF plays a critical role in neuronal …

Brain-derived neurotrophic factor (BDNF) is a versatile neurotrophic factor that has been
implicated in cell survival, cell differentiation, axonal growth, and activity-dependent synaptic …

Alzheimer's disease (AD) is a senile dementia characterized by amyloid plaques,
neurofibrillary tangles, and synaptic and cell loss. The “amyloid cascade” hypothesis …

An emerging body of data suggests that the early onset of Alzheimer's disease (AD) is
associated with decreased brain-derived neurotrophic factor (BDNF). Because BDNF plays …

Brain-derived neurotrophic factor (BDNF) promotes the function and survival of the major
neuronal types affected in Alzheimer disease, such as hippocampal, cortical and basal …

Astrocytes, the most abundant type of glia in the brain, are considered to play a key role in
Alzheimer's disease (AD) pathologies. In a cell culture study, we have previously shown that …

Brain‐derived neurotrophic factor (BDNF) is critical for the function and survival of neurons
that degenerate in the late stage of Alzheimer's disease (AD). There are two forms of BDNF …

Brain-derived neurotrophic factor (BDNF) is a critical molecule for learning and memory.
Brain BDNF levels correlate with cognitive status. BDNF is downregulated in Alzheimer's …

Brain-derived neurotrophic factor (BDNF) improves molecular, cellular, and behavioral
measures of neural dysfunction in genetic models of Alzheimer's disease (;). However …

Alzheimer's disease may be due to a deficiency in neurotrophin protein or receptor
expression. Consistent with this hypothesis, a reduction in BDNF mRNA expression has …