Approximately 5%–10% of breast cancers are due to genetic predisposition caused by
germline mutations; the most commonly tested genes are BRCA1 and BRCA2 mutations …

Background Genetic testing for BRCA1 and BRCA2 is offered typically to selected women
based on age of onset and family history of cancer. However, current internationally …

Breast cancer is the most prevalent cancer in Asian females, and the incidence of breast
cancer has been increasing in Asia. Be cause Asian patients develop breast cancer at a …

Background Mutations in BRCA1 and BRCA2 confer an increased risk to breast and other
cancers, but to date there have only been limited numbers of studies of BRCA1-and BRCA2 …

Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of
BRCA1 and BRCA2 mutations in different populations. The prevalence and effect of BRCA 1 …

We determined the prevalence and characteristics of BRCA1/2 germline mutations in a large
cohort of Chinese women with breast cancer. A total of 5931 unselected Chinese women …

Abstract The Korean Hereditary Breast Cancer (KOHBRA) study was established to evaluate
the prevalence and spectrum of BRCA1/2 mutations in Korean breast cancer patients at risk …

A number of molecular epidemiological studies have been conducted the screening for
BRCA1 and BRCA2 mutations in breast cancer patients with a positive family history of …

Purpose: The aim of this study is to further understand the status of BRCA1 and BRCA2
mutation among Chinese high-risk breast cancer patients in multiple-ethnic regions of …

Background A large number of distinct mutations in the BRCA1 and BRCA2 genes have
been reported worldwide, but little is known regarding the role of these inherited …