Heart failure (HF) is a syndrome causing a huge burden in morbidity and mortality
worldwide. Current medical therapies for HF are aimed at suppressing the neurohormonal …

Despite recent advances in therapy, heart failure remains a major cause of mortality and
morbidity and is a growing healthcare burden worldwide. Alterations in myocardial energy …

Despite advances in treatment, chronic heart failure is still associated with significant
morbidity and a poor prognosis. The scope for further advances based on additional …

This comprehensive review explores the critical role of fatty acid (FA) metabolism in cardiac
diseases, particularly heart failure (HF), and the implications for therapeutic strategies. The …

Fatty acids are the main substrates used by mitochondria to provide myocardial energy
under normal conditions. During heart remodeling, however, the fuel preference switches to …

The failing heart is characterized by alterations in energy metabolism, including
mitochondrial dysfunction and a reduction in fatty acid (FA) oxidation rate, which is partially …

Alterations in cardiac energy metabolism contribute to the severity of heart failure. However,
the energy metabolic changes that occur in heart failure are complex and are dependent not …

To maintain its high energy demand the heart is equipped with a highly complex and
efficient enzymatic machinery that orchestrates ATP production using multiple energy …

In the advanced stages of heart failure, many key enzymes involved in myocardial energy
substrate metabolism display various degrees of down-regulation. The net effect of the …

The chronically failing heart has been shown to be metabolically abnormal, in both animal
models and in patients. Little data are available on the rate of myocardial glucose, lactate …